Results 121 to 130 of about 3,038,209 (307)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Application interactive methods and technologies of teaching chemistry

open access: yesChemistry Teacher International, 2019
Currently, chemistry education solves problems related to the definition of new values in order to improve the quality of education, personal development of the pupils, and problems of the teaching strategies that will stimulate the interest and ...
Sadykov Timur, Čtrnáctová Hana
doaj   +1 more source

Recommendation, Class Repeating, and Children's Ability: German School Tracking Experiences [PDF]

open access: yes
While the 2006 Progress in International Reading Literacy Study assesses the average ability of German primary school students as being higher than average, the Programme for International Student Assessment studies (2000, 2003, 2006) ranks German ...
Carsten Ochsen
core  

Cost effectiveness of school-located influenza vaccination programs for elementary and secondary school children. [PDF]

open access: yes, 2019
BackgroundStudies have noted variations in the cost-effectiveness of school-located influenza vaccination (SLIV), but little is known about how SLIV's cost-effectiveness may vary by targeted age group (e.g., elementary or secondary school students), or ...
Albertin, Christina S   +7 more
core  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte   +13 more
wiley   +1 more source

Introduction of Hydrosphere Environmental Problems in Lower Secondary School Chemistry Lessons

open access: yesEducation Sciences
The 2030 Agenda for Sustainable Development focuses on ensuring a healthy environment for present and future generations by avoiding risks associated with consumption, exploitation of natural resources and pollution.
Taja Klemen, Iztok Devetak
doaj   +1 more source

An Exploration of Experiences and Outcomes of Alaska Native Graduates of Mt. Edgecumbe High School [PDF]

open access: yes, 2009
In Alaska’s schools, indigenous1 students are the most at risk of any ethnic group of failing to thrive; they drop out more frequently, are less likely to graduate, and generally have lower educational attainment than non-Native students(Martin and ...
DelMoral, Brit, Hirshberg, Diane
core   +1 more source

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