Results 31 to 40 of about 175,417 (206)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Assessment of the Quality of Life in Patients with Multiple Sclerosis
Pielęgniarstwo Neurologiczne i Neurochirurgiczne, 2021 Introduction. Each progressive incurable disease has an impact on the level and quality of life of those affected, on their family, professional and social roles.
Halina Kalandyk, Jolanta Dyndur
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Journal of Education, Health and Sport, 2017 Chronic Obstructive Pulmonary Disease is a disease that is characterized by persistent bronchial obstruction (by lowering FEV). This handicap shows progressive tendencies and is basically irreversible. Due to the number of deaths and deaths in the world,
Agata Ulenberg +5 more
doaj +3 more sources
Рациональная фармакотерапия в кардиологии, 2016 Effect of hyperlipidemia on morbidity and mortality in elderly patients is considered. Authors also cover issues of efficacy and safety of lipid-lowering therapy in primary and secondary prevention of cardiovascular diseases in patients ≥80 years of age ...
E. A. Ushkalova +4 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Febuxostat in patients with hyperuricemia and gout: is the nephroprotective effect real?
Современная ревматологияHyperuricemia (HU) and gout are independent risk factors for chronic kidney disease (CKD). Worldwide, the increasing prevalence of CKD leads to a deterioration in the quality and duration of life of patients and an increase in mortality.
M. S. Eliseev, Ya. I. Kuzmina
doaj +1 more source
POSTHERPETIC NEURALGIA – CURRENT FACTS AND THERAPEUTIC POSSIBILITIES [PDF]
Romanian Journal of Medical Practice, 2019 Neuropathic pain in postherpetic neuralgia has an impact on important aspects of the patient’s day to day life, lowering it’s quality. Understanding the complex pathophysiological mechanisms of postherpetic neuralgia and assesing the patient’s pain ...
Ana-Maria Cioti +4 more
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source