Results 61 to 70 of about 655,560 (301)

Comparing nonsynergy gamma models and interaction models to predict growth of emetic Bacillus cereus for combinations of pH and water activity values [PDF]

, 2011
This research aims to test the absence (gamma hypothesis) or occurrence of synergy between two growth-limiting factors, i.e., pH and water activity (aw), using a systematic approach for model selection.
Biesta-Peters, E.G., Gorris, L.G.M., Reij, M.W., Zwietering, M.H.   +3 more
core   +3 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Cardiovascular and mortality risks in migrant South Asians with type 2 diabetes: are we winning the battle? [PDF]

, 2017
Purpose of Review: We seek to describe the relationship between diabetes mellitus and cardiovascular risk in migrant South Asians compared to native white Europeans, and to determine the temporal change in this relationship over recent years.
Johns, Emma, Sattar, Naveed
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Female sex and overweight are associated with a lower quality of life in patients with myasthenia gravis: a single center cohort study

BMC Neurology, 2023
Background Myasthenia gravis (MG) affects individuals as a chronic autoimmune disease for many years. Commonly, chronic diseases significantly reduce the patients’ quality of life.
Hannah Wilcke, Stefanie Glaubitz, Fabian Kück, Christoph Anten, David Liebetanz, Jens Schmidt, Jana Zschüntzsch   +6 more
doaj   +1 more source

The Consequences Of The Lower Limp Amputation In Health Related Quality Of Life

, 2017
ABSTRACT Introduction:The lower limb amputation have significant effects on physical and mental health of patients, while at the same time consists a serious socio-economic problem, as it is associated with increased morbidity, multiple surgeries, prolonged hospital stay and increased disability rates.
Athanasia, Vozani, Georgia, Fasoi, Evridiki, Kampa, Martha, Kelesi   +3 more
openaire   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Effects of two-year vitamin B12 and folic acid supplementation on depressive symptoms and quality of life in older adults with elevated homocysteine concentrations: additional results from the B-Proof study, an RCT [PDF]

, 2016
Lowering elevated plasma homocysteine (Hcy) concentrations by supplementing vitamin B12 and folic acid may reduce depressive symptoms and improve health-related quality of life (HR-QoL) in older adults.
André Uitterlinden, Anke Enneman, Annelies Ham, Brenda Penninx, Bryan, Elisa de Koning, Elske Brouwer-Brolsma, Evelien Sohl, Garretsen, Harm van Marwijk, Jacques, Janneke van Wijngaarden, Karin Swart, Lamers, Lisette de Groot, Natasja van Schoor, Nathalie van der Velde, Nikita van der Zwaluw, Papakostas, Paul Lips, Petra Elders, Rosalie Dhonukshe-Rutten, Suzanne van Dijk, Vidal-Alaball, Ware   +24 more
core   +7 more sources

Development of a whole life cycle cost model for electrification options on the UK rail system [PDF]

, 2016
Projects to deliver Overhead Line Equipment (OLE) electrification on the UK rail infrastructure system presents technical challenges which the rail industry in Britain have not traditionally had to consider.
Baguley, Paul, Giuntini, L., Kirkwood, Leigh   +2 more
core   +1 more source