Results 41 to 50 of about 538,001 (326)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Planar Ultrametric Rounding for Image Segmentation [PDF]

open access: yes, 2015
We study the problem of hierarchical clustering on planar graphs. We formulate this in terms of an LP relaxation of ultrametric rounding. To solve this LP efficiently we introduce a dual cutting plane scheme that uses minimum cost perfect matching as a ...
Fowlkes, Charless C., Yarkony, Julian
core   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

open access: yesFEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan   +2 more
wiley   +1 more source

The Improvement on the Boundedness and Norm of a Class of Integral Operators on Lp Space

open access: yesJournal of Function Spaces, 2015
We prove the condition “c is neither 0 nor a negative integer” can be dropped on the boundedness of a class of integral operators Sa,b,c on Lp space, which improves the result by Krues and Zhu.
Lifang Zhou, Jin Lu
doaj   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

open access: yesMolecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun   +5 more
wiley   +1 more source

Serum Neurofilament Light Chain in Multiple Sclerosis: Superiority of Age‐ and BMI‐Corrected Z Scores/Percentiles Over Absolute Cutoff Values for Prediction of Treatment Response

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Prognostication of disease course and prediction of treatment response in multiple sclerosis is an unmet need. We compared the performance of serum neurofilament light chain Z scores (age‐ and BMI‐adjusted) with absolute concentrations for the prediction of response to disease‐modifying therapy.
Maximilian Einsiedler   +43 more
wiley   +1 more source

Arens Algebras and Matricial Spaces

open access: yesВестник КазНУ. Серия математика, механика, информатика, 2019
Let M be a finite von Neumann algebra equipped with a finite faithful normal trace and let Lp(M; ) be the corresponding noncommutative Lp space of -measurable operators associated with the couple (M; ), 1 ≤ p < ∞. Let MN be the algebra of all complex N
Denis Potapov, Fedor Sukochev
doaj   +1 more source

Unintentional aortic puncture during lumboperitoneal shunt placement

open access: yesInterdisciplinary Neurosurgery, 2021
Unintentional aortic puncture has not been reported during lumboperitoneal (LP) shunt placement. A patient with normal pressure hydrocephalus (NPH) had arrest of cerebrospinal fluid (CSF) flow after each of 3 punctures for LP shunt placement.
Alexander E. Shearin, Nazih A. Moufarrij
doaj   +1 more source

Isometric Embedding in lp-spaces

open access: yesEuropean Journal of Combinatorics, 1990
We prove that every n-point subset of lp (1 ⩽ p ⩽ ∞) embeds isometrically into lpm, where lpm, and that for 1 ⩽ p < 2 this result is essentially best possible.
openaire   +2 more sources

Lived and care experiences of chronic musculoskeletal shoulder pain in Australian adults: A qualitative study

open access: yesArthritis Care &Research, Accepted Article.
Objectives Australian evidence on lived and care experiences of chronic musculoskeletal shoulder pain (CMSP), irrespective of disorder classification or disease, is limited. However, such evidence is important for person‐centred care and informing local service pathways and care guidelines or standards.
Sonia Ranelli   +8 more
wiley   +1 more source

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