Results 141 to 150 of about 1,828,400 (307)

Lr-Stream: Using latency and resource aware scheduling to improve latency and throughput for streaming applications

, 2021
Lr-Stream: Using latency and resource aware scheduling to improve latency and throughput for streaming ...
H Yan (7775612), D Sun (7893608), X Zheng (7940567), Shang Gao (13094151), X Liu (7756691), H He (4699546)   +5 more
core  

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response

, 2010
Microcystins (MCs), a cyclic heptapeptide hepatotoxins. are mainly produced by the bloom-forming cyanobacerium Microcystis, which has become an environmental hazard worldwide.
Sun, Xiaoyun, Song, LR, CAS, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Beijing, Peoples R China, Dai, Guofei, Chung, Fung-Lung, Gan, Nanqin, Song, Lirong, Mi, Lixin   +6 more
core  

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

LEAF RUST RESISTANCE IN COMMON WHEAT VARIETIES AND LINES FROM THE COLLECTION OF THE VAVILOV PLANT INDUSTRY INSTITUTE CARRYING ALIEN GENETIC MATERIAL

Вавиловский журнал генетики и селекции, 2015
Leaf rust resistance was estimated in 83 common wheat accessions from the collection of the Vavilov Institute carrying alien genetic material. Eight accessions with seedling resistance and 27 accessions with adult plant resistance were found.
A. S. Sadovaya, E. I. Gultyaeva, O. P. Mitrofanova, E. L. Shaidayuk, A. G. Hakimova, E. V. Zuev   +5 more
doaj  

Phytopathological screening and identification of Lr genes in wheat varieties and winter triticale of Russian selection

South of Russia: ecology, development
Aim. Phytopathological assessment of leaf rust resistance and identification of Lr genes in 15 zoned varieties of wheat and winter triticale.The material for the study was 15 varieties of winter wheat and triticale of domestic selection. The criteria for resistance to leaf rust were: type of reaction (score) and degree of damage (%), area under the ...
V. D. Rudenko, G. V. Volkova, O. A. Kudinova, O. F. Vaganova   +3 more
openaire   +2 more sources

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

The LR-FHSS System: Simulation and Validation

embargoed_20270709In recent years, advancements in satellites technology and a soared demand for bandwidth have spurred the creation and deployment of new cost-effective LEO constellations.
BONAVENTURA, LUCA
core  

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source