Results 211 to 220 of about 1,828,400 (307)

An engineered ferritin nanocage co-delivery system for targeted hair cells protection and hearing loss attenuation. [PDF]

Theranostics
Zhang J, Zheng Z, Zhang J, Ma X, Li Z, Lin H, Nie G, Liang M, Ding H, He Y.   +9 more
europepmc   +1 more source

Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment

Annals of Neurology, EarlyView.
Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring, Enya Abler, Jakub Vavra, Kristina Mayer, Johannes Dorst, Zeynep Elmas, Maximilian Wiesenfarth, Lars Richter, Susanne Petri, Martin Regensburger, Peter Reilich, Bogdan Bjelica, Rea Lumi, Patrick Süß, Hayrettin Tumani, Markus Otto, Jochen H. Weishaupt, Albert C. Ludolph, Patrick Oeckl   +18 more
wiley   +1 more source

Unraveling cell-cell communication through spatial transcriptomics: a review of computational methods. [PDF]

Brief Bioinform
Yang J, Shyr Y, Liu Q.
europepmc   +1 more source

Zirkuläre, Photogeschützte mRNA für Lichtinduzierte Aktivierung der Translation zu späten Zeitpunkten

Angewandte Chemie, EarlyView.
Eine klickbare, photogeschützte 5′‐Kappe (CyCliCap) zur Herstellung von zyklischer, Click‐Cap enthaltender mRNA (Cyclic Click Cap‐mRNA), die bis zur Bestrahlung beachtlich stabil und translational stumm ist, ermöglicht die Aktivierung der Translation in Zellen zu späten Zeitpunkten mittels Lichts. ZUSAMMENFASSUNG mRNA ist eine neue Impfstofftechnologie
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source

Lateral Root Development: Molecular Mechanisms and Adaptive Regulation. [PDF]

Plant Cell Environ
Yang H, Huang F, Li X, Zeng X, Zhu L, Tursunniyaz M, Xu C, Li S, He X, Wang Y, Zhang L, Fang L.   +11 more
europepmc   +1 more source

Single-cell RNA-seq and spatial transcriptomics characterize CD8⁺ exhausted T cells in pancreatic ductal adenocarcinoma. [PDF]

iScience
Mao J, Yan C, Mei Y, Yao Y, Yang X, Zhuang J, Yu K, Gu G, Zhang H, Zheng Y, Wei Y, Han S, Yan Q.   +12 more
europepmc   +1 more source

Circular Photocaged mRNA for Light‐induced Late‐stage Activation of Translation

Angewandte Chemie International Edition, EarlyView.
A clickable photo‐caged 5′ cap (CyCliCap) allows to make Cyclic Click Cap‐containing mRNA (CyCliCap‐mRNA) which is remarkably stable and translationally muted until irradiated, allowing for late‐stage activation of translation in cells by light. ABSTRACT mRNA is a new medical modality as vaccine and raises hopes to become a protein replacement agent ...
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source

Beyond the gene: isoform diversity as a key contributor to human brain disorders. [PDF]

Curr Opin Genet Dev
Ma Y, Jops C, Gandal MJ.
europepmc   +1 more source

Genome-wide machine learning analysis of anosmia and ageusia with COVID-19. [PDF]

PLoS One
Pietan L, Phillippi E, Melo M, El-Shanti H, Smith BJ, Darbro B, Braun T, Casavant T.   +7 more
europepmc   +1 more source

Environmental and Genetic Effects on the Composition of Palm Oil From Hybrid Plant Clones of Caiaué and Oil Palm

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT The interspecific hybrids (IEH OxG) obtained from the crossing of Elaeis oleifera (Eo) and Elaeis guineensis (Eg) are resistant to some diseases that affect Eg in some regions of South America, and commercial growing in several countries has been established.
Rosemar Antoniassi, Ricardo Lopes, Sidney Pacheco, Allan Eduardo Wilhelm, Rui Alberto Gomes Junior, Adelia Ferreira de Faria‐Machado, Raimundo Nonato Vieira Cunha   +6 more
wiley   +1 more source