Results 31 to 40 of about 2,934 (189)
Marine DrugsThis open-label, two-part, phase Ib drug–drug interaction study investigated whether the pharmacokinetic (PK) and safety profiles of lurbinectedin (LRB), a marine-derived drug, are affected by co-administration of itraconazole (ITZ), a strong CYP3A4 ...
Irene Moreno +11 more
doaj +1 more source
The immunosuppressive effects and mechanisms of loureirin B on collagen-induced arthritis in rats
Frontiers in Immunology, 2023 IntroductionRheumatoid arthritis (RA) is a common disease mainly affecting joints of the hands and wrists. The discovery of autoantibodies in the serum of patients revealed that RA belonged to the autoimmune diseases and laid a theoretical basis for its ...
Yan Zou +27 more
doaj +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT Phytocannabinoids are bioactive metabolites derived from the Cannabis sativa plant. They have garnered attention due to their recreational uses and therapeutic potential. Although various analytical strategies have been employed for their analysis, mass spectrometry (MS) coupled to chromatographic separation is superior due to its sensitivity ...
Radwa Mahmoud +2 more
wiley +1 more source
EJNMMI Radiopharmacy and ChemistryBackground Mesothelin is a glycoprotein overexpressed in various cancers, with limited expression in healthy tissues. The single-domain antibody (sdAb, or nanobody) A1-His has previously successfully been validated in mice for the SPECT imaging of ...
Émilien N’Guessan +10 more
doaj +1 more source
PharmaceuticalsThis open-label, two-way, crossover, phase Ib drug–drug interaction study investigated whether the pharmacokinetics (PKs) and safety profile of lurbinectedin (LRB) are affected by co-administration of a moderate CYP3A4 inducer (bosentan, BOS) in adult ...
Irene Moreno +11 more
doaj +1 more source
Influence of Ambient Temperature on Seismic Response of SMA–LRB Isolated Bridge
工程科学与技术, 2022 With the development of seismic isolation technology, the service environment of the isolated bridge is becoming increasingly complicated, and the effect of ambient temperature on the seismic performance of isolated bridge should be considered urgently ...
Yan SHI +5 more
doaj
Heliyon, 2023 Melasma is a pigmentation disease with refractory and high recurrence risk. Therefore, finding effective treatment has become the focus of research. This study aimed to reveal the mechanism of Licorice rose beverage (LRB) in treating melasma from the ...
Dan Zhai +14 more
doaj +1 more source
Characterization of a stress tolerance‐defective mutant of Lactobacillus rhamnosus LRB
Molecular Oral Microbiology, 2019 Abstract Lactobacillus rhamnosus is a lactic acid bacterium that survives diverse ecological niches, including the human oral cavity and gastrointestinal tract. L. rhamnosus is an acidogenic bacterium that produces copious amounts of lactic acid.
Saswati Biswas +2 more
openaire +3 more sources
Does Surgical Approach Influence Benchmark Attainment in Intrahepatic Cholangiocarcinoma?
World Journal of Surgery, EarlyView.Intrahepatic cholangiocarcinoma (ICC) is a rare malignancy with rising incidence and poor prognosis. Surgical resection remains the only curative option, with outcomes driven by R0 margins and lymphadenectomy (LND). While open liver resection (OLR) is standard, laparoscopic (LLR) and robotic liver resection (RLR) are increasingly used, with concerns ...
Delphine Gastineau +40 more
wiley +1 more source
Abundance of Collembola in Biopore Infiltration Holes Filled with Organic Waste and Animal Waste
Florea: Jurnal Biologi dan PembelajarannyaGarbage and flooding are environmental problems that need attention. One solution to dealing with organic waste and flooding is the creation of biopore absorption holes (LRB). Organic waste can be processed into compost with the help of soil animals such
Leo Eladisa Ganjari +1 more
doaj +1 more source