Results 31 to 40 of about 2,923 (184)
EJNMMI Radiopharmacy and ChemistryBackground Mesothelin is a 40 kDa glycoprotein overexpressed in several cancers, including triple-negative breast cancer (TNBC). The anti-mesothelin single-domain antibody (sdAb, or nanobody) A1 can serve as a radio-theranostic agent, but random DOTA ...
Émilien N’Guessan +12 more
doaj +1 more source
PharmaceuticalsThis open-label, two-way, crossover, phase Ib drug–drug interaction study investigated whether the pharmacokinetics (PKs) and safety profile of lurbinectedin (LRB) are affected by co-administration of a moderate CYP3A4 inducer (bosentan, BOS) in adult ...
Irene Moreno +11 more
doaj +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT Phytocannabinoids are bioactive metabolites derived from the Cannabis sativa plant. They have garnered attention due to their recreational uses and therapeutic potential. Although various analytical strategies have been employed for their analysis, mass spectrometry (MS) coupled to chromatographic separation is superior due to its sensitivity ...
Radwa Mahmoud +2 more
wiley +1 more source
EJNMMI Radiopharmacy and ChemistryBackground Mesothelin is a glycoprotein overexpressed in various cancers, with limited expression in healthy tissues. The single-domain antibody (sdAb, or nanobody) A1-His has previously successfully been validated in mice for the SPECT imaging of ...
Émilien N’Guessan +10 more
doaj +1 more source
Marine DrugsThis open-label, two-part, phase Ib drug–drug interaction study investigated whether the pharmacokinetic (PK) and safety profiles of lurbinectedin (LRB), a marine-derived drug, are affected by co-administration of itraconazole (ITZ), a strong CYP3A4 ...
Irene Moreno +11 more
doaj +1 more source
Influence of Ambient Temperature on Seismic Response of SMA–LRB Isolated Bridge
工程科学与技术, 2022 With the development of seismic isolation technology, the service environment of the isolated bridge is becoming increasingly complicated, and the effect of ambient temperature on the seismic performance of isolated bridge should be considered urgently ...
Yan SHI +5 more
doaj
Heliyon, 2023 Melasma is a pigmentation disease with refractory and high recurrence risk. Therefore, finding effective treatment has become the focus of research. This study aimed to reveal the mechanism of Licorice rose beverage (LRB) in treating melasma from the ...
Dan Zhai +14 more
doaj +1 more source
rDNAmine: A New Tool for the Analysis of Long Repetitive Sequences
Yeast, EarlyView.This work introduces a novel approach for analysing long repetitive genomic sequences, combining a method to isolate large DNA molecules from individual chromosomes. We also describe the bioinformatics tool rDNAmine, which enables the isolation of long‐repeat sequences from reads obtained using the Oxford Nanopore method, as well as their preliminary ...
Agnieszka Czarnocka‐Cieciura +1 more
wiley +1 more source
Pharmaceutical Biology, 2022 Context Linum is the largest genus of the Linaceae family; the species of this genus are known to have anticancer activity.Objective In this study, ethyl acetate extracts of L. numidicum Murb. (EAELN) and L. trigynum L.
Ryma Mouna +6 more
doaj +1 more source
Animal Conservation, EarlyView.The gopher tortoise (Gopherus polyphemus), a keystone species and ecosystem engineer, has declined by ~80% over the past century due to primarily habitat loss. In a 28‐year resurvey of federally protected Mobile County and state‐protected Baldwin County, we found tortoise populations persisted at ~59% and ~31% of sites, respectively, with significant ...
Robin B. Lloyd Jr. +4 more
wiley +1 more source