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The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane. [PDF]

PLoS Genetics, 2016
Bardet-Biedl syndrome (BBS) is a highly pleiotropic autosomal recessive disorder associated with a wide range of phenotypes including obesity. However, the underlying mechanism remains unclear. Here, we show that neuronal BBSome is a critical determinant
Deng-Fu Guo +8 more
doaj +1 more source

Low‐threshold cutaneous mechanoreceptors on the foot sole have enhanced sensitivity when skin temperature is elevated

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of microneurography recordings used to examine the effects of local skin heating on cutaneous mechanoreceptor responses in the human foot (left panel). A microelectrode inserted into a peripheral nerve records single‐unit activity from tactile afferent fibres while controlled mechanical stimuli are applied ...
Erika E. Howe +4 more
wiley +1 more source

Investigating the Performance of Isolation Systems in Improving the Seismic Behavior of Urban Bridges. A Case Study on the Hesarak Bridge

Archives of Civil Engineering, 2019
This paper investigates the influence of isolation systems on the seismic behavior of urban reinforce concrete bridge. The performance of the Hesarak Bridge constructed in Karaj city, Iran with two isolation systems; i.e.
Edalati Ali Akbar, Tahghighi Hossein
doaj +1 more source

Efficacy and Safety of Subcutaneous Efgartigimod PH20 in Adults With Primary Immune Thrombocytopenia (ADVANCE SC): A Multicenter, Randomized, Double‐Blinded, Placebo‐Controlled, Phase 3 Trial

American Journal of Hematology, Volume 101, Issue 7, Page 1494-1506, July 2026.
ABSTRACT Primary autoimmune thrombocytopenia (ITP) is characterized by thrombocytopenia, bleeding, and reduced health‐related quality of life. In the Phase 3 ADVANCE IV study, intravenous efgartigimod induced significant platelet count responses versus placebo in patients with chronic ITP. ADVANCE SC, a Phase 3, multicenter, randomized, double‐blinded,
Nichola Cooper +546 more
wiley +1 more source

BCL‐2 and MCL1 co‐inhibition enhances glucocorticoid therapy in preclinical models of infant KMT2A‐rearranged acute lymphoblastic leukaemia

British Journal of Haematology, EarlyView.
Mawar Karsa +19 more
wiley +1 more source

PolyProline Predictor: A web server for empirical sequence‐based prediction of polyproline II helices

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Polyproline II (PPII) helices are extended left‐handed secondary structures increasingly recognized for their roles in molecular recognition, signaling and within intrinsically disordered regions of proteins. Despite their functional importance, predicting regions with propensity to form PPII helices from sequence alone remains challenging due
Rubén López‐Sánchez +3 more
wiley +1 more source

Full-Scale Pseudo-Dynamic Test for Bridge Retrofitted With Seismic Isolations

The Baltic Journal of Road and Bridge Engineering, 2008
This paper presents the performance of a retrofitted bridge with a seismic isolation. To validate the seismic performance of retrofitted bridge experimentally, four full-scale reinforced concrete bridge piers with fixed support conditions were fabricated
Kyoung-Bong Han, Jun Myoung Park, Sun-Kyu Park +2 more
doaj

Monoclonal antibody to rat apoC: multiple binding to apoC-I on lipoproteins increases its affinity constant.

Journal of Lipid Research, 1985
Using solid phase systems, the kinetics of binding of monoclonal antibody (LRB 45, IgG2b,kappa) to apoC-I and apoC-I on lipoproteins were investigated. At 25 degrees C, the association constant of LRB 45 antibody to apoC-I (3.56 X 10(6) M-1 X sec-1) was ...
L Wong
doaj +1 more source

Periodontitis and Periodontal Conditions in Systemically Healthy Children and Adolescents

Journal of Clinical Periodontology, Volume 53, Issue 7, Page 1100-1198, July 2026.
ABSTRACT Objective To answer the PICoS question ‘in systemically healthy children and adolescents (Population), what are the main features of periodontitis, necrotising periodontal diseases (NPD) and other periodontal conditions (periodontal abscesses, endo‐periodontal lesions, traumatic occlusal forces, prosthesis‐ and tooth‐related factors ...
Inbar Eshkol‐Yogev +5 more
wiley +1 more source

Predictive Value of TMJ Tomographic Parameters for Hypermobility‐Related Outcomes and Mouth Opening Capacity

Journal of Oral Rehabilitation, Volume 53, Issue 7, Page 1363-1370, July 2026.
Tomographic TMJ parameters showed limited predictive value for hypermobility‐related outcomes. Male sex was consistently associated with greater mouth opening, while increased age reduced the odds of TMJ subluxation. Structural imaging features demonstrated weak associations with functional measures, reinforcing the multifactorial nature of TMJ ...
Samilla Pontes Braga +6 more
wiley +1 more source

lead rubber bearing
seismic response