Results 101 to 110 of about 28,054 (245)

LRRK2 secretion in exosomes is regulated by 14-3-3 [PDF]

, 2017
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset Parkinson's disease (PD). Emerging evidence suggests a role for LRRK2 in the endocytic pathway. Here, we show that LRRK2 is released in extracellular microvesicles (i.e. exosomes)
Chen, Dongquan, Cowell, Rita M., Daher, João P.L., Dokland, Terje, Fraser, Kyle B., Galemmo, Robert A., Kojima, Kyoko, Mobley, James A., Moehle, Mark S., Moore, Darren J., Siegal, Gene P., Standaert, David G., Stewart, Carrie A., Tsika, Elpida, Webber, Philip J., West, Andrew B., Williams, Jeri Y., Yacoubian, Talene A., Ye, Tong   +18 more
core  

Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy body pathology [PDF]

, 2018
LRRK2, the gene encoding the multidomain kinase Leucine-Rich Repeat Kinase 2 (LRRK2), has been linked to familial and sporadic forms of Parkinson's disease (PD), as well as cancer, leprosy and Crohn's disease, establishing it as a target for discovery ...
Arber, Charles, Bandopadhyay, Rina, Cookson, Mark R, Lewis, Patrick A., Mamais, Adamantios, Manzoni, Claudia, Nazish, Iqra, Sonustun, Berkiye, Warner, Thomas T., Wray, Selina   +9 more
core   +1 more source

Prognosis in Parkinson's Disease: An Individual Patient Data Meta‐Analysis of Six European Incidence Cohorts

Movement Disorders, EarlyView.
Abstract Background An accurate understanding of prognosis in Parkinson's disease (PD) is important for patient information provision, personalized treatment, and clinical trial design, but most previous research has been biased towards younger, healthier patients.
Angus D. Macleod, David J. McLernon, Marta Camacho, Caroline H. Williams‐Gray, Rachael A. Lawson, Alison J. Yarnall, David Bäckström, Lars Forsgren, Jodi Maple‐Grødem, Guido Alves, Ole‐Bjørn Tysnes, Carl E. Counsell, Parkinson's Incidence Cohorts Collaboration, Thomas Foltynie, Sarah L. Mason, Ruwani Wijeyekoon, Jonathan Evans, David P. Breen, Gemma Cummins, Krista Farrell, Kirsten Scott, Tom Stoker, Julia Greenland, Natalie Valle Guzman, Lucy Collins, Simon Stott, Jan Linder, Mona Edström, Jörgen Andersson, Linda Eriksson, Gun‐Marie Hariz, Magdalena Domellöf, Michaela Dreetz Gjerstad, Kenn Freddy Pedersen, Elin Bjelland Forsaa, Veslemøy Hamre Frantzen, Anita Laugaland, Johannes Lange, Karen Simonsen, Eldbjørg Fiske, Ingvild Dalen, Bernd Müller, Geir Olve Skeie, Marit Renså, Wenche Telstad, Aliaksei Labusau, Jane Kastet, Ineke HogenEsch, Marianne Kjerandsen, Liv Kari Håland, Karen Herlofson, Solgunn Ongre, Siri Bruun, David Burn, Lynn Rochester, Gordon W. Duncan, Tien K. Khoo, Kate S. M. Taylor, Robert Caslake, David J. M. McGhee, Diane Swallow, Joanne Gordon, Clare Harris, Ann Hayman, Nicola Johannesson, Hazel Forbes, Valerie Angus, Alasdair Finlayson, David Dawson, Katie Wilde, David Ritchie, Artur Wozniak, Adrian Martin   +72 more
wiley   +1 more source

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity [PDF]

, 2017
Mutations in LRRK2 are one of the primary genetic causes of Parkinson's disease (PD). LRRK2 contains a kinase and a GTPase domain, and familial PD mutations affect both enzymatic activities.
Aebischer, Patrick, Bandopadhyay, Rina, Boon, Joon Y., Citro, Allison, Collins, James J., Derada Troletti, Claudio, Dusonchet, Julien, Glauser, Liliane, Glicksman, Marcie A., Guillily, Maria, Li, Hu, Liu, LiQun, Liu, Min, Mamais, Adamantios, Moore, Darren J., Saha, Shamol, Schneider, Bernard L., Stafa, Klodjan, Wolozin, Benjamin, Youmans, Katherine L., Yue, Zhenyu   +20 more
core  

LRRK2 in Transcription and Translation Regulation: Relevance for Parkinson’s Disease [PDF]

, 2012
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder and is characterized by the selective loss of dopaminergic neurons and the presence of Lewy bodies.
Sébastien S Hébert, Sébastien S Hébert, Véronique eDorval, Véronique eDorval   +3 more
core   +2 more sources

An Assessment of LRRK2 Serine 935 Phosphorylation in Human Peripheral Blood Mononuclear Cells in Idiopathic Parkinson’s Disease and G2019S Cohorts

Journal of Parkinson’s Disease, 2020
The phosphorylated form of LRRK2, pS935 LRRK2, has been proposed as a target modulation biomarker for LRRK2 inhibitors. The primary aim of the study was to characterize and qualify this biomarker for therapeutic trials of LRRK2 inhibitors in Parkinson’s ...
Shalini Padmanabhan, Thomas A. Lanz, Donal Gorman, Michele Wolfe, Alison Joyce, Carlos Cabrera, Rosemary Lawrence-Henderson, Najah Levers, Neal Joshi, Thong C. Ma, Christopher Liong, Sushma Narayan, Roy N. Alcalay, Samantha J. Hutten, Marco A.S. Baptista, Kalpana Merchant   +15 more
doaj   +1 more source

The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System

Frontiers in Neuroscience, 2020
The leucine-rich repeat kinase 2 (LRRK2), the most common causative gene for autosomal-dominant familial Parkinson’s disease, encodes a large protein kinase harboring multiple characteristic domains.
Tomoki Kuwahara, Takeshi Iwatsubo
doaj   +1 more source

The Global Parkinson's Disease Genetics (GP2) Genome Browser

Movement Disorders, EarlyView.
Abstract Background Large‐scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinson's disease (PD) risk and disease‐causing variants, we developed an open‐access, summary‐level genomic data browser.
Zih‐Hua Fang, Riley H. Grant, Dan Vitale, Carlos F. Hernandez, Samantha Hong, Hampton L. Leonard, Mary B. Makarious, Lara M. Lange, Matthew Solomonson, Peter Heutink, Allison A. Dilliott, Kamalini Ghosh Galvelis, Mike A. Nalls, Andrew B. Singleton, Cornelis Blauwendraat, the Global Parkinson's Genetics Program (GP2)   +15 more
wiley   +1 more source

LRRK2: an éminence grise of Wnt-mediated neurogenesis? [PDF]

, 2013
The importance of Leucine-Rich Repeat Kinase 2 (LRRK2) to mature neurons is well-established, since mutations in PARK8, the gene encoding LRRK2, are the most common known cause of Parkinson’s disease.
Daniel C Berwick, Kirsten eHarvey
core   +3 more sources

Cellular effects of LRRK2 mutations [PDF]

Biochemical Society Transactions, 2012
Mutations in LRRK2 (leucine-rich repeat kinase 2) are a relatively common cause of inherited PD (Parkinson's disease), but the mechanism(s) by which mutations lead to disease are poorly understood. In the present paper, I discuss what is known about LRRK2 in cellular models, focusing specifically on assays that have been used to tease apart the effects
openaire   +2 more sources