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The role of LRRK2 in cytoskeletal dynamics
Biochemical Society Transactions, 2018Leucine-rich repeat kinase 2 (LRRK2), a complex kinase/GTPase mutated in Parkinson's disease, has been shown to physically and functionally interact with cytoskeletal-related components in different brain cells. Neurons greatly rely on a functional cytoskeleton for many homeostatic processes such as local and long-distance vesicle transport, synaptic ...
Laura Civiero +3 more
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Mechanisms of Mutant LRRK2 Neurodegeneration
2017LRRK2 mutations are associated with the loss of neurons, that is to say toxicity, in patients and in experimental model systems. However, the mechanisms by which mutations can be linked to neurodegeneration are not fully defined. Here I will argue that mechanism in this context encompasses a variety of levels of information. Mutations or alterations in
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Hyperactive LRRK2 kinase impairs the trafficking of axonal autophagosomes
Autophagy, 2021C Alexander Boecker, Erika L F Holzbaur
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Proceedings of the National Academy of Sciences of the United States of America, 2021
Yuriko Sobu +2 more
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Yuriko Sobu +2 more
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The Cell Biology of LRRK2 in Parkinson's Disease
Molecular and Cellular Biology, 2021Farbod Shavarebi, Annie Hiniker
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