Results 151 to 160 of about 117,947 (317)
Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
Small, EarlyView.The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho +4 morewiley +1 more sourceActivatable smart contrast agents for photoacoustic imaging
Smart Molecules, EarlyView.This review highlights recent advances in smart activatable photoacoustic imaging (PAI) contrast agents, which dynamically modulate their optical properties in response to external stimuli or microenvironmental cues. It discusses their molecular design, activation mechanisms, biomedical applications, and future prospects for clinically tailored use ...Donghyeon Oh, Jihye Lee, Suyoung Park, Juyoung Yoon, Won Jong Kim, Chulhong Kim +5 morewiley +1 more sourceImplications of Changing the Diagnostic Criteria for Gestational Diabetes Mellitus (CDC4G): A Healthcare Cost Analysis Alongside a Stepped Wedge Cluster Randomised Trial
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Objective
To estimate the effect on healthcare resource use after introducing the World Health Organization diagnostic criteria (WHO‐2013) for gestational diabetes mellitus (GDM) compared to former criteria in Sweden (SWE‐GDM). Design
A cost‐analysis alongside the Changing Diagnostic Criteria for Gestational Diabetes (CDC4G) randomised ...Maryam de Brun, Naimi Johansson, David Simmons, Scott Montgomery, Kerstin Berntorp, Stefan Jansson, Ulla‐Britt Wennerholm, Anna‐Karin Wikström, Helena Strevens, Fredrik Ahlsson, Verena Sengpiel, Elisabeth Storck‐Lindholm, Martina Persson, Kerstin Petersson, Carina Ursing, Linda Ryen, Helena Backman +16 morewiley +1 more sourceThe Therapeutic Potential of Farm Dust Extracts in a Mouse Model of Eosinophilic Inflammation
Allergy, EarlyView.Farm dust extract (FDE) treatment reduces airway eosinophilia, mucus overproduction, and MHC‐II expression on DCs, limiting antigen presentation and Th2 inflammation. It increases PD‐L1 on DCs, promoting T cell deactivation. Additionally, FDE enhances Tregs and upregulates CTLA‐4, reinforcing suppression.Rabia Ülkü Korkmaz, Jimmy Omony, Xiaomei Tan, Markus Klotz, Guilherme Dragunas, Sirui Chen, Soni Shankhwar, Zeynep Ertüz, Christoph Müller, Mohab Ragab, Aicha Jeridi, Romina Augustin, Janna Nawroth, Theodore S. Kapellos, Bettina Rankl, Ali Önder Yildirim, Erika von Mutius +16 morewiley +1 more sourceStructural and organisational impacts of peri‐operative enhanced care services in the UK: a Retrospective Evaluation of Postoperative Alternatives to Critical Care (REPACC)
Anaesthesia, EarlyView.Summary Introduction
The enhanced care model of peri‐operative care has evolved to meet increasing surgical demand, aiming to relieve pressure on critical care and prevent unnecessary cancellation of surgery. Despite widespread adoption of these facilities in the UK, no resources currently describe the national landscape of enhanced care or the ...Christopher Oddy, Dominic Lowcock, Thomas W. Davies, Sarah Towey, Mark Burnett, Amanda Davis, Gareth Davey, Adam Green, Olivia Bools, Michael Coulton, Henry Lewith, Paolo Perella, Danny J. N. Wong, the Pan‐London Perioperative Audit and Research Network Committee, the REPACC Study Investigators, Mohamed Hussein, Kazi Farhana Akhter, Konye Anthonia Ochonogor, Tanya Elizabeth Spencer, Nicky Carroll, Zain Malik, Anja Sabine Daniela Kuttler, Madeleine Gray, Cathy Zhang, Marie Smith, Snehal Kale, Sumeet Gajbhar, Nathalie Stevenson, Jennifer Mullan, Joshua Hulman, Ken Inweregbu, Juan Michael Jansen van Vuuren, Jatinder Stanley, Arun Sahni, Caroline Phillips, Lara Allen, Jessica Hickman, Georgina Singleton, Lisa Grimes, Simon Chung Yan Lam, Dinesh Tumu, Gayatri Khanvelkar, Rohit Patil, Prasad Lanka, James Womersley, Emma Smith, Helen Köwitz Arroyo, Jahnavi Priya, Dafydd Lloyd, Ceit Cunningham, Richard Snooks, Aimi Lara Emilie Jeanes, Lara Jeanes, Tamsyn Glover, Roger Davies, Emily J Croft, Nipun Agarwal, Thomas Craven, Barnaby Dykes, Gianfranco Messina, Islam Abousharkh, James Brown, Sarah Kipling, Sodha Meera, Stephanie Davis, Maria Chereshneva, Sundar Raj Ashok, Craig Morris, Thomas Bacarese‐Hamilton, Jack Gallagher, Nicola K Pearson, Katarzyna Anna Marasinska, William Roberts, Vikram Singh, Benjamin Ledsom, Bhavna Bhalla, Sioned Phillips, David Bailey, Jacob Lawson, Adriano Ferrante, Aldo Alberto Bignamini, Adam Beebeejaun, David Bailey, Georgia Boniface, Jen VanRoss, Larissa Matveeva, Sherpal Singh, Soo Yoon, Zhi Yap, Divya Gautam, Omnia Askar, Sanooj Soni, Priyanka Tewari, Ankita Deshpande, Kimberly Kok, Neil Gaurav Verma, Nigel West, Tanumoy Maulick, John Robson, Ikechukwu Igwebuike, Balaji Rajamani, Fionnuala Durrant, John McDonald, Jude Spedding, Leo Worley, Ritoo Kapoor, Ivana Kaljevic, Sarah Brown, Benedicte Sjoflot, Sanya Patel, Akshay Pradhan, Arif Ahmed, Ee Lyn Chan, Jenny Olsson, Ravi Bhatia, Marie Harrison, Michael Burnley, Deepak Subramani, Rachel Holmes, Moh’d Adnan Hasan Yousef, Lucy Marshall, Rebecca King, William Flinn, Ayman Salmona, Hisham Mohamed Riad, Prajith Sanjeewa Amarasekara, Ruth Charlesworth, Valeria Ortiz Martinez, Zahid Furqan, Alix Gerard, Louise White, Catherine Moriarty, Caroline Thomas, Benjamin Kidner, Benjamin Kidner, Rebecca Holyland, Varun Aggarwal, Talia Wieder, Gursimren Lidder, Robert Connolly, Pietro Ferranti, Camila Maria de Oliveira, Manju Sharma, Meithem Ali, Amy Ackerley, Rebecca Seaman, Kate Stannard, James Wood, Eslam Elsayed, Arun Prasad Ravichandran, Prerna Shaktawat, Rashid Hussain, Samyuktha Raj, Yousuf Abusamra, Gareth Kitchen, Alexander Fowler, Ameila Milton, Chloe Start, Adam Mills, Benjamin Hofland‐Ward, George Humble, Kate Preston, Matthew Smith, Milena Vannahme, Brendan Sloan, Catherine Chapman, Helen Ivatt, Steve Davies, Tristan Edey, Nia Wyn Davies, Justin Maini, Thomas Hirst, Dona Saha, Drew Harding, Gilbert Thomas‐Black, Georgia Mathieson, Francis Elechi, Kavita Patel, Maia Shivani Yashwini Back, Freddie Weyman, Ketan Kataria, Thomas Fowler, Bhavesh Gohil, Rohit Hanmanta Bhandari, Sonali Gupta, AlexKumar Patel, Kritika Rathour, Rohit Rohit, Estelle Maria D'Cunha, Ammara Khan, Anjali Ashok Menon, Arun Thirunavukarasu, Mansi Gandhi, James Goetz, Maria Pikoula, Menaka Iyer, Sarah Hudson, Shweta Appiah, Sophie Ledsome, Kirstin Strathie, Tejal Kothari, Yashasvi Perera, James Day, Alexander Johnson, Adam Phillips, Elin Rowlands, Elizabeth Grant, Jessica Phillips, Anna Forbes, Thomas Reed, Joseph A Gallaher, Rebecca Mitchell, Hayley Kaye, Charlene Barter, Tamer Younes, Moustafa Zahra, Sameer Qasala, Sajith Damodaran, Hannah Nugent, Mandeep Phull, Adam J Boulton, Ahmed Ibrahim, Brigitte Baxter, Orla Gillman, Sejal Modasia, Graham Bolton, Karthik Iyer, Michael P Coulton, Paul Bramley, Aaron Owen, Jonathan Emberey, Anil Hormis, Clare Windsor, Rebecca Murphy, Ana Orozco, Maxime Gibbons, Robin Helsby, Arun Mohanraj, Alexandra Gray‐Renfrew, Alison Thorne, Elizabeth Whittaker, Jesymin Jia Min Choong, Vikram Nagarajan, Anuradha Kurvey, Claire Pollington, Saadia Shahzad, Stephanie Alsop, Madhu Balasubramaniam, Eleanor Shaw, Rachel Grant, Alexandra Cockroft, David Ivan Wells, Isabel Greaves, Oliver Eastwood, Judith Cheong‐Leen, Thomas Capstick, Urbi Sen, Leanne Darwin, Uneesa Mahmood, Alastair Savage, Adedolapo Adejumo, Sam Murgatroyd, John Mensah, Victoria Lowden, Alex Chatburn, Christopher Harrison, Erica Morris, Jake Winterbottom, Samuel Allen, Viren Kadodwala, Matthew Needham, Matthew Holland, Matthew Holland, Eleanor Lewis, Gareth Ifan James Davey, Nicoletta Fossati, Hannah Gardiner, Prateek Nalwaya, Adyasha Das, Duncan Baily, Cindy Luximon, Alex Wickham, James Heggie, Aamer Mughal, Daniel Greaves, Narendra Siddaiah, Gabriel Chee En Ngui, Thomas Hawthorne, Katie Wilson, Kirstie Wright, Nuruljannah Ismail, Tochukwu Bede Oluh, Murray Williams, Ashli Antoine, Peter M Odor, Naomi Jordan, Sarah Elgarf, Gruffudd Thomas, Catherine Britton‐Jones, Bejal Patel, Shona Sandhu, Ben Wooldridge, Saarah Rana, Zi Chao Soo, Amitesh Chugh, Danboy Ayodeji, Andrew Tang, James P King, Diana Neely, Nithin Jayan, Najade Sheriff, Anna Williams, Beatrice Meilak, Joe Woodcock, Morwenna Coultate, Venkat Sundaram, Matthew Sinnott, Mayur Murali, Shriya Kumar, Joanna Wong, Farzana Husain, Muska Miller, Elizabeth Brown, Jan Man Wong, Kim Rhodes, Lucy Liu, Daveena Meeks, Ben Milne, Jenny Olsson, Mitul Patel, Shilen Shah +330 morewiley +1 more sourceThe use of deidentified organ donor testes for research
Andrology, EarlyView.Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan +4 morewiley +1 more sourceTargeting MCL‐1 and MAPK overcomes venetoclax resistance in FLT3‐ITD‐positive AML cells harbouring activating PTPN11 (SHP‐2) mutations
British Journal of Haematology, EarlyView.Summary
Venetoclax (VEN)‐based therapies have improved the treatment of acute myeloid leukaemia (AML); however, the emergence of resistance remains a major limitation. Mutations in protein tyrosine phosphatase (PTP) non‐receptor type 11 (PTPN11) and FMS like tyrosine kinase 3 with internal tandem duplication (FLT3‐ITD) are common in resistant patients ...Maximilian Fleischmann, Ole Hansen, Diana Voigtländer, Julia Bechwar, Lenny‐Joseph Schwietzer, Sanja Bahr, Ulf Schnetzke, Mike Fischer, Florian H. Heidel, Tina M. Schnöder, Jörg P. Müller, Andreas Hochhaus, Sebastian Scholl +12 morewiley +1 more sourcePhycocyanobilin biosynthesis in Galdieria sulphuraria requires isomerization of phycoerythrobilin synthesized by bilin reductases
The FEBS Journal, EarlyView.The biosynthesis of bilins, tetrapyrroles essential for light harvesting and sensing, is performed by specific enzymes (FDBRs). In Galdieria sulphuraria, both phycobiliprotein types bind phycocyanobilin, despite lacking the canonical synthesizing gene PCYA. Instead, PEBA and PEBB are encoded, producing phycoerythrobilin, proposed to be later isomerized Federica Frascogna, Nathan C. Rockwell, Jana Hartmann, Julie M. Mudler, Nicole Frankenberg‐Dinkel +4 morewiley +1 more source
