Results 191 to 200 of about 12,929 (212)

UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors. [PDF]

Nature
Yeo MJR, Zhang O, Xie X, Nam E, Payne NC, Gosavi PM, Kwok HS, Iram I, Lee C, Li J, Chen NJ, Nguyen K, Jiang H, Wang ZA, Lee K, Mao H, Harry SA, Barakat IA, Takahashi M, Waterbury AL, Barone M, Mattevi A, Carr SA, Udeshi ND, Bar-Peled L, Cole PA, Mazitschek R, Liau BB, Zheng N.   +28 more
europepmc   +1 more source

LMK235 ameliorates inflammation and fibrosis after myocardial infarction by inhibiting LSD1-related pathway. [PDF]

Sci Rep
Lv F, Xie L, Li L, Lin J.
europepmc   +1 more source

Crosstalk Between Abiotic and Biotic Stresses Responses and the Role of Chloroplast Retrograde Signaling in the Cross-Tolerance Phenomena in Plants. [PDF]

Cells
Kamran M, Burdiak P, Karpiński S.
europepmc   +1 more source

Emerging Insights into Sall4's Role in Cardiac Regenerative Medicine. [PDF]

Cells
Yang J.
europepmc   +1 more source

LSD1 inhibits the invasion and migration of breast cancer through exosomes. [PDF]

Sci Rep
Zhang N, Chen Z, Xin B, Shi Y, Yao Y, Yang J, Wang X, Hu X.   +7 more
europepmc   +1 more source

Lysine and arginine methylation of transcription factors. [PDF]

Cell Mol Life Sci
Giaimo BD, Ferrante F, Borggrefe T.
europepmc   +1 more source

Histone lysine methylation modifiers controlled by protein stability. [PDF]

Exp Mol Med
Park S, Cho JH, Kim JH, Kim JA.
europepmc   +1 more source

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Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1

Journal of Medicinal Chemistry, 2021
As a flavin adenine dinucleotide (FAD)-dependent monoamine oxidase, lysine specific demethylase 1 (LSD1/KDM1A) functions as a transcription coactivator or corepressor to regulate the methylation of histone 3 lysine 4 and 9 (H3K4/9), and it has emerged as a promising epigenetic target for anticancer treatment. To date, numerous inhibitors targeting LSD1
Xing-Jie Dai, Ying Liu, Lei-Peng Xue, Xiao-Peng Xiong, Ying Zhou, Yi-Chao Zheng, Hong-Min Liu   +6 more
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A comprehensive comparative study on LSD1 in different cancers and tumor specific LSD1 inhibitors

European Journal of Medicinal Chemistry, 2022
LSD1 was significantly over-expressed in several cancer types, and its aberrant overexpression was revealed to play a crucial role in the initiation and progression of cancer. Several LSD1 inhibitors that were discovered and developed so far were found to be effective in attenuating tumor growth in both in vivo and in vitro studies.
Jianshu Dong, Waqar Pervaiz, Bilal Tayyab, Dié Li, Lei Kang, Huimin Zhang, Huimin Gong, Xinli Ma, Jian Li, Clement Agboyibor, Yuefeng Bi, Hongmin Liu   +11 more
openaire   +2 more sources