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LSD1 inhibition: a therapeutic strategy in cancer?
Expert Opinion on Therapeutic Targets, 2012The role of epigenetic dysfunction in cancer is increasingly appreciated. This has raised the question as to whether enzymes that regulate the structure and function of chromatin might represent novel therapeutic targets. The histone demethylase LSD1 is one such candidate and novel, potent inhibitors are under development.The literature on LSD1 (also ...
Lynch, James T. +2 more
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Drug Design Concepts for LSD1‐Selective Inhibitors
The Chemical Record, 2018AbstractLysine‐specific demethylase 1 (LSD1) is one of the flavin‐dependent oxidases and is involved in many cellular processes by controlling the methylation of histone H3. Recently, it has been reported that LSD1 is associated with several diseases such as cancer, metabolic disorders, and psychiatric diseases.
Yosuke, Ota, Takayoshi, Suzuki
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Advances Toward Lsd1 Inhibitors for Cancer Therapy
Future Medicinal Chemistry, 2017LSD1 has become an important biologically validated epigenetic target for cancer therapy since its identification in 2004. LSD1 mediates many cellular signaling pathways and is involved in the initiation and development of cancers. Aberrant overexpression of LSD1 has been observed in different types of cancers, and inactivation by small molecules ...
Xiaoli, Fu, Peng, Zhang, Bin, Yu
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LSD1 inhibitors: a patent review (2010-2015)
Expert Opinion on Therapeutic Patents, 2016Lysine demethylase 1 (LSD1) plays an important role in mediating the expression of genes involved in cancer and non-cancer diseases such as viral infections, cardiovascular and neurodegenerative disorders. It is involved in a number of processes from adipogenesis to cell adhesion to viral latency, regulating several cell pathways related with ...
STAZI, Giulia +3 more
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CSF3R and SETBP1 getting high on LSD1
Blood, 2022Helong Zhao, Michael W. Deininger
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Coaching LSD1 to ignore acetylation
Nature Chemical BiologyJoshua C. Black, Tatiana G. Kutateladze
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