Results 201 to 210 of about 466,444 (273)

Attenuation of Influenza a Virus into Live Vaccines Through C‐End Degrons

Advanced Science, EarlyView.
Naturally occurring C‐end degrons are exploited to design proteolysis‐targeting live attenuated influenza vaccines. C‐end degron tagging of viral M1 protein promotes proteasome‐dependent degradation, resulting in robust attenuation in host cells while permitting scalable production in engineered cells.
Ping Wang, Le Li, Yunfang Chen, Le Tong, Zhen Li, Rong Yu, Quan Shen, Qikai Wang, Jihuan Hou, Qisi Zhang, Xu Si, Ning Wang, Demin Zhou, Wen‐xia Tian, Longlong Si   +14 more
wiley   +1 more source

Correction: Castro-Muñoz et al. Merging Proline:Xylitol Eutectic Solvent in Crosslinked Chitosan Pervaporation Membranes for Enhanced Water Permeation in Dehydrating Ethanol. <i>Membranes</i> 2023, <i>13</i>, 451. [PDF]

Membranes (Basel)
Castro-Muñoz R, Plata-Gryl M, Boczkaj G.   +2 more
europepmc   +1 more source

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

Circular Permutation of the <i>E. coli</i> Heat-Labile Enterotoxin Pentameric B Subunit for Mucosal Vaccine Adjuvant Design. [PDF]

ACS Omega
Hsu SH, Xie DY, Tsai CY, Lin WS, Wu CY, Lin YH, Liu WC, Wu SC, Sue SC.   +8 more
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Correction to "Antiosteoporotic Effect of Combined Extract of <i>Morus alba</i> and <i>Polygonum odoratum</i>". [PDF]

Oxid Med Cell Longev
europepmc   +1 more source

Generalized Dystonia in a Patient With Wilson Disease 5 Years After Liver Transplant: A Case Report. [PDF]

Tremor Other Hyperkinet Mov (N Y)
Edwards E, Coleman B, Feldman M, Charles JH, Shpiner DS.   +4 more
europepmc   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Defining the Society of Pediatric Liver Transplantation (SPLIT) research agenda: A Delphi consensus project. [PDF]

Hepatol Commun
Wadhwani SI, Spector PR, Feldman AG, Furuya KN, Hartjes K, Jarasvaraparn C, Kelly B, Lerret SM, Mysore K, Pawaria A, Rosenthal P, Shui A, Slowik V, Taylor S, Vittorio J, Valentino PL, Society of Pediatric Liver Transplantation (SPLIT).   +16 more
europepmc   +1 more source

Design of a Cobalt‐Free Maraging Steel with Ultra‐High Strength of 2.3 GPa Through Additive Manufacturing

Advanced Science, EarlyView.
A computationally designed, cobalt‐free maraging steel tailored for additive manufacturing achieves an ultra‐high tensile strength of 2.3 GPa with 5.7% elongation. This exceptional strength‐ductility synergy stems from high‐density core‐shell Ni3Ti/NiAl nanoprecipitates, a crack‐resistant composition, and a fine equiaxed grain structure enabled by ...
Hu Li, Shubo Gao, Liming Tan, Weiming Ji, Liuliu Han, Kun Zhou, Yong Liu   +6 more
wiley   +1 more source