Results 51 to 60 of about 1,457 (180)

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

What happened to the Early Precambrian granulite complexes of the Bug region (Ukrainian shield) and the Limpopo belt (South Africa) and how to stratify them? A tectonist’s view

Геофизический журнал, 2022
The author reviews two alternative approaches (stratigenic-metamorphogenic and deformation-metamorphogenic) to the geology and mapping of the Earth’s oldest crust rocks that were metamorphized in РТ-conditions of the granulite facies, on the examples of
O.B. Gintov
doaj   +1 more source

Development of CCMb: A Low‐Mg Calcite Reference Material for In Situ Measurement of δ18O, δ13C and Selected Trace Elements

Geostandards and Geoanalytical Research, EarlyView.
Key Points Low‐Mg calcite RM developed for in situ microanalysis applications in palaeoclimatology (δ18O, δ13C; Mg, Sr m/m). New data for calcite CRM IAEA‐603 (δ18O, δ13C by SIMS and GS‐IRMS; Mg m/m). No detectable IMF effect of Mg on SIMS δ18O determinations for mass fractions < 3650 μg g‐1.
Andreas T. Hertwig, Maciej G. Śliwiński, Irene Cantarero, Richard A. Stern, Carles Fàbrega, Jakub T. Śliwiński, Thomas Ludwig, František Majs, William Nachlas, John H. Fournelle, Xavier Llovet, Rachelle B. Turnier, David Parcerisa, Anna Travé   +13 more
wiley   +1 more source

Assessment and Correction of Non‐Linearity Effects for In Situ Rb‐Sr Geochronology Applied to High 87Rb/86Sr Mica

Geostandards and Geoanalytical Research, EarlyView.
Key Points Measurement of 86Sr at count rates < 1500 cps can result in statistical bias. Non‐linear signals in analogue detection mode (e.g., Rb) present a challenge for accurately dating high 87Rb/86Sr mica (> 1000). Accounting for these considerations, high 87Rb/86Sr mica are dated here with accuracies of ∼ 1%.
Duane C. Petts, William J. Davis, Simon E. Jackson, Jamie A. Cutts, Janina Czas, Alfredo Camacho   +5 more
wiley   +1 more source

Petrogenesis and implications of the Dupangling compound granite in southern Hunan Province, China: Constraints from mineralogical chemistry, zircon U-Pb age, geochemistry and Nd-Hf isotope

Dizhi lixue xuebao, 2022
In this paper, zircon SHRIMP U-Pb geochronology, petrology, mineral chemistry, petrogeochemistry, Sm-Nd and Lu-Hf isotopes were studied for the eastern part of the Dupangling pluton, which is located at the western section of Nanling at the junction of ...
CHEN Di, LUO Peng, ZENG Zhifang, LIANG Enyun, PENG Yunyi, JIA Pengyuan, XIONG Miao, ZOU Guangjun   +7 more
doaj   +1 more source

Isotopic composition of Yb and the determination of Lu concentrations and Lu/Hf ratios by isotope dilution using MC‐ICPMS [PDF]

Geochemistry, Geophysics, Geosystems, 2004
We report Yb isotopic data for the purpose of accurately correcting measurements of Lu and Lu/Hf ratios during Multicollector Inductively Coupled Plasma Mass Spectrometer (MC‐ICPMS) analysis. The Yb isotopic ratios agree with recent results of Chu et al.
Jeff D. Vervoort, P. Jonathan Patchett, Ulf Söderlund, Mark Baker   +3 more
openaire   +1 more source

Multi‐Elemental Analysis for Geographical Tracing of Chickpeas Produced in Nearby Locations Around a Protected Geographical Indication

Plant, Cell &Environment, Volume 49, Issue 7, Page 4341-4351, July 2026.
ABSTRACT The multi‐elemental profile has repeatedly been proposed as a reliable indicator of the geographical origin of plant‐derived foods, as mineral composition accurately reflects the local soil geochemistry and environmental factors. However, this approach may fail in distinguishing specimens from nearby locations, which are expected to be exposed
Ana Sayago, Raúl González‐Domínguez, Ángeles Fernández‐Recamales   +2 more
wiley   +1 more source

Lu–Hf Isotope Systematics of Carbonatites [PDF]

Goldschmidt Abstracts, 2020
Ladislav Polák, Lukáš Ackerman, Tomáš Magna, Michael Bizimis, Vladislav Rapprich   +4 more
openaire   +1 more source

Ages and sources of detrital zircons from the Early Mesozoic metasedimentary rocks of the Un’ya-Bom terrane of the Mongol-Okhotsk fold belt: results of U-Th-Pb and Lu-Hf isotope studies

Геодинамика и тектонофизика, 2019
The U-Pb and Lu-Hf isotope studies have been performed to investigate detrital zircons from metaterrigenous deposits (Nel, Kurnal and Amkan formations) of the Un’ya-Bom terrane of the eastern part of the Mongol-Okhotsk fold belt.
V. A. Zaika, A. A. Sorokin
doaj   +1 more source

Progressively Fenitised Schist and Carbonatitic Clasts From a Metasomatic Aureole Beneath the Alkalic Dunedin Volcano, Otago, New Zealand

New Zealand Journal of Geology and Geophysics, Volume 69, Issue 2, June 2026.
Clasts of albite‐porphyroblastic quartzofeldspathic schist, derived from the Otago Schist basement, occur within the Port Chalmers Breccia, a diatreme at the centre of the Dunedin stratovolcano, New Zealand. Schists have undergone varying degrees of replacement reactions (at temperatures of 300° to >500°C) producing hornfelses, with Ca‐ and K‐enriched ...
Alan F. Cooper
wiley   +1 more source