Results 271 to 280 of about 10,580,440 (338)

Deferasirox Derivatives as Inhibitors of Kallikrein‐Related Peptidases Associated to Neurodegenerative Diseases

ChemMedChem, EarlyView.
Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina Aït Amiri, Valérie Lefort, Anthony Nina‐Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source

Stalling of the endometrial decidual reaction determines the recurrence risk of miscarriage. [PDF]

Sci Adv
Muter J, Kong CS, Nebot MT, Tryfonos M, Vrljicak P, Brighton PJ, Dimakou DB, Vickers M, Yoshihara H, Ott S, Tan BK, Bennett PR, Quenby S, Richter A, Van de Velde H, Lucas ES, Rawlings TM, Brosens JJ.   +17 more
europepmc   +1 more source

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, Accepted Article.
Over the past decades extensive scientific research in the fields of chemistry and pharmaceutical chemistry has led to the synthesis and study of numerous chemical compounds with diverse therapeutic applications. Many of these compounds feature heterocyclic aromatic structures, including six‐, five‐, and four‐membered rings.
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

Recycling Spent Synthesis Liquor for Enhanced Production of ZIF‐67: Characterization and Morphological Insights

ChemNanoMat, EarlyView.
Zeolitic imidazolate framework‐67 (ZIF‐67) is synthesized by recycling spent synthesis liquor that contains unreacted 2‐methylimidazole. This recycling process improves the yield of ZIF‐67 while preserving the dodecahedral rhombic shape of the particles. As the liquor is recycled, both the particle size and surface area increase. This study reports the
Lucas Battiston, Barbara Gerbelli, Fabiano Yokaichiya, Ivan Barros, Kátia Oliveira, Cícero Ávila‐Neto   +5 more
wiley   +1 more source

Erector spinae plane block versus caudal epidural block in pediatric surgery: a systematic review and meta-analysis of randomized clinical trials. [PDF]

Braz J Anesthesiol
Masiero BB, Cavalcante D, Akbarpoor F, Pascoal CAD, Al-Sharif L, Halfeld FF, Bendaham LCAR, Viana P, Haryianto JN, Rasia MLS, Cunha MCA, Tesche AD, de Oliveira JCR, Lombardi RA.   +13 more
europepmc   +1 more source

Phase Transformation Processes in Co‐Precipitated Cu/Zn/Zr Methanol Catalyst Precursors – Insights into Suspension Aging form Ultra‑Fast Nucleation

ChemPlusChem, Accepted Article.
Catalyst precursors for methanol synthesis prepared by co‑precipitation, such as Cu/Zn‑based hydroxycarbonates, are generally formed within two steps. The initial precipitation phase (nucleation) leads to a suspension from which, in a subsequent aging phase, the final solid precursor is formed, thus providing the structural and morphological features ...
Lucas Warmuth, Thomas A. Zevaco, David Guse, Michael Zimmermann, Matthias Kind, Stephan Pitter   +5 more
wiley   +1 more source

Long-Term Efficacy of Pembrolizumab and the Clinical Utility of ctDNA in Locally Advanced dMMR/MSI-H Solid Tumors. [PDF]

Nat Commun
LaPelusa M, Qiao W, Iorgulescu B, San Lucas F, Patel K, Bhamidipati D, Thomas JV, You N, Foo WC, Maru D, Thirumurthi S, Morris V, Kopetz S, Overman M, Ludford K.   +14 more
europepmc   +1 more source

Population Pharmacokinetic/Toxicodynamic Model for Polymyxin B in Critically Ill Patients to Identify the Risk of Nephrotoxicity

Clinical Pharmacology &Therapeutics, EarlyView.
Polymyxins are used against highly resistant Gram‐negative pathogens, and nephrotoxicity (acute kidney injury, AKI) is the major dose‐limiting adverse effect. We aimed to develop a well‐informed population pharmacokinetic/toxicodynamic (PK/TD) model using the largest polymyxin B‐treated critically ill patient population studied to inform polymyxin B ...
Patrick O. Hanafin, Ramya Mahadevan, Gauri G. Rao, Alexandre P. Zavascki, Ana Maria Sandri, Andrea Kwa, Marc H. Scheetz, Christine J. Kubin, Jayesh Shah, Benjamin P.Z. Cherng, Michael T. Yin, Jiping Wang, Lu Wang, David P. Calfee, Maureen Bolon, Anthony W. Purcell, Roger L. Nation, Jason M. Pogue, Jian Li, Keith S. Kaye   +19 more
wiley   +1 more source

Pediatric Educational Discussion Scenarios: Reflect, Inspire, Support, and Empower (PEDS-RISE)-A Difficult Patient Encounter Video Scenario. [PDF]

MedEdPORTAL
Payne C, Zieve H, Lucas CT, Shekarabi N, Vasa M, Reddy V, Bauer K, Afghani B.   +7 more
europepmc   +1 more source