Results 271 to 280 of about 10,580,440 (338)

Deferasirox Derivatives as Inhibitors of Kallikrein‐Related Peptidases Associated to Neurodegenerative Diseases

open access: yesChemMedChem, EarlyView.
Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali   +11 more
wiley   +1 more source

Stalling of the endometrial decidual reaction determines the recurrence risk of miscarriage. [PDF]

open access: yesSci Adv
Muter J   +17 more
europepmc   +1 more source

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

open access: yesChemMedChem, Accepted Article.
Over the past decades extensive scientific research in the fields of chemistry and pharmaceutical chemistry has led to the synthesis and study of numerous chemical compounds with diverse therapeutic applications. Many of these compounds feature heterocyclic aromatic structures, including six‐, five‐, and four‐membered rings.
Claudia Finamore   +5 more
wiley   +1 more source

Recycling Spent Synthesis Liquor for Enhanced Production of ZIF‐67: Characterization and Morphological Insights

open access: yesChemNanoMat, EarlyView.
Zeolitic imidazolate framework‐67 (ZIF‐67) is synthesized by recycling spent synthesis liquor that contains unreacted 2‐methylimidazole. This recycling process improves the yield of ZIF‐67 while preserving the dodecahedral rhombic shape of the particles. As the liquor is recycled, both the particle size and surface area increase. This study reports the
Lucas Battiston   +5 more
wiley   +1 more source

Erector spinae plane block versus caudal epidural block in pediatric surgery: a systematic review and meta-analysis of randomized clinical trials. [PDF]

open access: yesBraz J Anesthesiol
Masiero BB   +13 more
europepmc   +1 more source

Phase Transformation Processes in Co‐Precipitated Cu/Zn/Zr Methanol Catalyst Precursors – Insights into Suspension Aging form Ultra‑Fast Nucleation

open access: yesChemPlusChem, Accepted Article.
Catalyst precursors for methanol synthesis prepared by co‑precipitation, such as Cu/Zn‑based hydroxycarbonates, are generally formed within two steps. The initial precipitation phase (nucleation) leads to a suspension from which, in a subsequent aging phase, the final solid precursor is formed, thus providing the structural and morphological features ...
Lucas Warmuth   +5 more
wiley   +1 more source

Long-Term Efficacy of Pembrolizumab and the Clinical Utility of ctDNA in Locally Advanced dMMR/MSI-H Solid Tumors. [PDF]

open access: yesNat Commun
LaPelusa M   +14 more
europepmc   +1 more source

Population Pharmacokinetic/Toxicodynamic Model for Polymyxin B in Critically Ill Patients to Identify the Risk of Nephrotoxicity

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Polymyxins are used against highly resistant Gram‐negative pathogens, and nephrotoxicity (acute kidney injury, AKI) is the major dose‐limiting adverse effect. We aimed to develop a well‐informed population pharmacokinetic/toxicodynamic (PK/TD) model using the largest polymyxin B‐treated critically ill patient population studied to inform polymyxin B ...
Patrick O. Hanafin   +19 more
wiley   +1 more source

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