Results 111 to 120 of about 613,108 (397)

La surprise du découvreur

open access: yesSociologies, 2013
The sociology of science has now integrated to its field of investigation findings considered unlikely, unexpected or surprising, as well as notions until then little assumed by scientists: chance, luck, serendipity or contingency.
François Lavie
doaj  

Glassy states in a shaken sandbox [PDF]

open access: yes, 2001
Our model of shaken sand, presented in earlier work, has been extended to include a more realistic `glassy' state, i.e., when the sandbox is shaken at very low intensities of vibration. We revisit some of our earlier results, and compare them with our new results on the revised model.
arxiv   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

Ludometrics: Luck, and How to Measure It [PDF]

open access: yesarXiv, 2018
Game theory is the study of tractable games which may be used to model more complex systems. Board games, video games and sports, however, are intractable by design, so "ludological" theories about these games as complex phenomena should be grounded in empiricism.
arxiv  

Luck and Identity [PDF]

open access: yesTheoretical Inquiries in Law, 2007
I take a close look at Bernard Williams’s paper "Moral Luck," which put this notion on the philosophical agenda. Williams’s focal example is the painter Paul Gauguin. According to Williams, Gauguin’s morally dubious decision to desert his family so as to pursue an artistic career can be redeemed only by his partially fortuitous success as a painter ...
openaire   +2 more sources

Moral Luck and The Unfairness of Morality [PDF]

open access: yes, 2019
Moral luck occurs when factors beyond an agent’s control positively affect how much praise or blame she deserves. Kinds of moral luck are differentiated by the source of lack of control such as the results of her actions, the circumstances in which she ...
Hartman, Robert
core  

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

open access: yesMolecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

Moral Luck from Bernard Williams’ Point of View

open access: yesJournal of Philosophical Investigations, 2016
Moral luck is an important issue in meta- ethics. Its conflict to principle of control make challenges to moral moral assessment, moral judgment and moral responsibility.
Zahra Khazai ; Fatemeh Tamaddon
doaj  

There is No Running Away from Fate

open access: yesGender Studies, 2018
At birth, everybody is assigned a fate that cannot be changed. In the Banat region, the belief in the powerful influence of the Fairy Godmothers on the new-born’s destiny is still alive.
Alexin Otilia Daniela
doaj   +1 more source

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