Results 61 to 70 of about 62,692 (304)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Luck and the Limits of Equality
, 2019 A recent movement within political philosophy called luck egalitarianism has attempted to synthesize the right’s regard for responsibility with the left’s concern for equality. The original motivation for subscribing to luck egalitarianism stems from the
Jeffers, Matthew
core +1 more source
Aristotle and Contemporary Theories of Luck
PhilosophiesContemporary theories of luck face problems when it comes to moral luck, that is, luck that nevertheless partially determines moral responsibility. Either they conceive of luck as chancy or modally fragile, which is too narrow and excludes cases such as ...
Marcella Linn
doaj +1 more source
Axiological Aspects in the Tale Medenata Pita by Konstantin Konstantinov
Zeszyty Cyrylo-Metodiańskie, 2018 The paper presents a linguo-cultural analysis of the tale Medenata Pita (The Honey Bread) by the Bulgarian writer Konstantin Konstantinov. The authors try to build a complex methodological apparatus for studying readers’ perceptions regarding the ...
Georgieva, Elitsa, Dushkova, Mira
doaj +1 more source
Taking chances: Gambling and Providence in Shakespeare’s Merchant of Venice
Etudes Epistémè, 2021 In this article I wish to explore how the pervading references to games in William Shakespeare’s Merchant of Venice pave the way for a reflection on the respective roles of chance, providence and human agency in shaping the characters’ destiny.
Louise Fang
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
UNCOVERING THE TRUE “WEALTH” OF HAPPINESS —EXAMINING THE LIMITATIONS THAT GOVERN CROESUS’ QUESTION ABOUT HAPPINESS AND ARISTOTLE’S SUBSEQUENT REPLY [PDF]
Analiza i Egzystencja, 2013 The goal of the article is to present the context in which we, modern readers and scholars, make meaningful use of the words “happiness,” “luck,” and “fortune.” This discussion starts by examining Croesus’s question to Solon, who is the happiest man on ...
Alon Segev
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source