Results 61 to 70 of about 616,598 (295)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
UNCOVERING THE TRUE “WEALTH” OF HAPPINESS —EXAMINING THE LIMITATIONS THAT GOVERN CROESUS’ QUESTION ABOUT HAPPINESS AND ARISTOTLE’S SUBSEQUENT REPLY [PDF]
Analiza i Egzystencja, 2013 The goal of the article is to present the context in which we, modern readers and scholars, make meaningful use of the words “happiness,” “luck,” and “fortune.” This discussion starts by examining Croesus’s question to Solon, who is the happiest man on ...
Alon Segev
doaj
Can huge market profits of the best investors be explained by a lottery winner's luck? [PDF]
Business & IT, 2019 In the years 1994-1996, I started to think about how much meaning luck has when trading stocks, FOREX, and corresponding derivatives. Therefore, I developed a simple formula, which describes how much your capital can grow if you have a rare lottery ...
Tommi P. Laiho
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Free Will, Self‐Creation, and the Paradox of Moral Luck [PDF]
, 2019 How is the problem of free will related to the problem of moral luck? In this essay, I answer that question and outline a new solution to the paradox of moral luck, the source-paradox solution.
Mickelson, Kristin M.
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Sociologies, 2013 The sociology of science has now integrated to its field of investigation findings considered unlikely, unexpected or surprising, as well as notions until then little assumed by scientists: chance, luck, serendipity or contingency.
François Lavie
doaj
Luck in Aristotle's Physics and Ethics [PDF]
, 2015 I discuss how Aristotle’s formulation of the problem of moral luck relates to his natural philosophy. I review well-known passages from Nicomachean Ethics I/X and Eudemian Ethics I/VII and Physics II, but in the main focus on EE VII 14 (= VIII 2).
Johnson, Monte
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source