Results 81 to 90 of about 390,913 (299)

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Epigenetic modulation of macrophage polarization prevents lumbar disc degeneration

, 2020
Yang Hou, Guodong Shi, Yongfei Guo, Jiangang Shi   +3 more
openalex   +2 more sources

Postoperative lumbar fusion paraspinal desmoid tumor case report

, 2022
Jenny Yan, J. Levi Chazen
openalex   +1 more source

Micro lumbar discectomy: Review and case report [PDF]

, 2021
Prakash Modha
openalex   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Lateral retroperitoneal approach for the treatment of a recumbent silkworm-like paravertebral schwannoma in the lumbar spine: a case report

Frontiers in Oncology
ObjectiveThis case report describes the surgical management of a recumbent silkworm-like paravertebral schwannoma in the lumbar spine resected via the lateral retroperitoneal approach.MethodsA lumbar paravertebral schwannoma resembling a “recumbent ...
Lanming Su, Wei Liu, Yingying Zhang, Feng Li, Yuanqin Liu, Ziyu Wang   +5 more
doaj   +1 more source

Association between hip flexor tightness and lumbar instability in adults

, 2023
Asghar Khan, Arshad Nawaz Malik
openalex   +2 more sources

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Association Between Lumbar Disc Herniation and Vertebral Endplate Modic Changes: An MRI-Based Study

Advanced Biomedical Research
Background: Low back pain (LBP) is a prevalent health concern with various causes, including lumbar disc herniation (LDH) and vertebral endplate Modic changes (MCs).
Pegah Torabi, Ghazaleh Jamalipour Soufi, Ali Hekmatnia, Hadi Ravanbod, Mehdi Teimouri, Mahdi Shahsavan, Farzaneh Hekmatnia, Mohammad Shahsavan   +7 more
doaj   +1 more source

Minimally Invasive Spinal Fusion Using Percutaneous Pedicle Screw Instrumentation Can Provide a Better Health-Related QOL in Early Stage Than Conventional Methods in the Treatment of Single-Level Degenerative Lumbar Spinal Diseases

, 2023
Masumi Iwabuchi, Ryoji Tominaga, Jun Komatsu, Osamu Shirado   +3 more
openalex   +2 more sources