Results 101 to 110 of about 441,593 (257)

L5 spondylolysis increases segmental mobility at the cranial adjacent level without altering intervertebral disc contact pressure

Frontiers in Bioengineering and Biotechnology
ObjectiveWhile lumbar spondylolysis has been biomechanically associated with subsequent spondylolisthesis and disc degeneration, its implications on cranial adjacent segments remain unclear.
Zhilin Ge, Bingde Zhao, Xu Xu, Lin Chen, Dongzhu Liang, Qingyang Kang, Zibo Gao, Junhua Luo, Jiheng Zhan, Jianquan Chen, Bo Zhang   +10 more
doaj   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

MRI-Based Evaluation of Lumbar Epidural Space Depth and Its Correlation with Anthropometric Factors in Saudi Adults

Tomography
Background: Epidural procedures benefit from a pre-procedural informed estimation of epidural depth, as anticipating the approximate distance can support safer needle placement and reduce technical difficulties during analgesia or anesthesia procedures ...
Ilhaam Alsaati, Khaleel Alyahya, Mohammed Alharbi, Zuhal Y. Hamd, Shaden Alhegail   +4 more
doaj   +1 more source

Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK‐Binding Osteoclastogenic Factor

Advanced Science, EarlyView.
Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park, Yeongkag Kwon, Yeonjin Lim, Jeong Woo Park, Hyun Jung Ji, Dongwook Lee, Jueun Lee, Sung‐Ho Yun, Sungho Jeong, Ho Seong Seo, Kun Cho, Cheol‐Heui Yun, Ok‐Jin Park, Seung Hyun Han   +13 more
wiley   +1 more source

Coexisting cervical and lumbar disc degeneration and associated MRI phenotypes: a large-scale population-based study

, 2017
Introduction: It remains unknown whether lumbar disc degeneration and patterns therein along with associated lumbar phenotypes (e.g. Modic changes, disc bulge/extrusion) are associated with coexisting cervical degenerative findings on magnetic resonance ...
Luk, KDK, Samartzis, D, Bow, HYC, Cheung, KMC, Karppinen, J   +4 more
core  

Lumbar Bone Stress Injuries in Cricket Fast Bowlers: A Review

Journal of Clinical Orthopaedics
Lumbar Bone Stress Injuries (LBSI) encompass a spectrum ranging from bone stress reactions to lumbar stress fractures (LSF). These injuries are among the most prevalent in cricket players, particularly fast bowlers.
Parth Bansal, Sarvdeep Singh Dhatt, Vishal Kumar, Sachin Kale, Ojasv Gehlot, Akhil Gailot   +5 more
doaj   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

RECOVERY OF LUMBOSACRAL PAINS AFTER LUMBAR DISC HERNIATION SURGERY [PDF]

, 2017
Background. Lumbar disc herniation is a suffering with increased incidence and a tendency to continuously decrease the age at which it starts. In disc disorders where pain is accentuated during walking and resting and does not give in to medical and ...
Anca JIANU
core   +1 more source