Results 111 to 120 of about 441,593 (257)

Influencing factors of work-related musculoskeletal disorders in neck, shoulder, and lumbar regions among workers wearing insulated gloves in power grid industry

环境与职业医学
BackgroundAs one of the primary operational methods in the power grid industry, the insulated glove working method imposes significant physical demands due to the constraints of insulating equipment and specific required postures, resulting in ...
Xuyang LIAO, Zekai LIANG, Qingsong CHEN, Chunguang DING, Runkun ZHANG, Guanlin LI   +5 more
doaj   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Adaptation of thoracic and lumbar curvature and spinal muscle activity under changing gravity

Frontiers in Physiology
IntroductionThe effect of micro-gravity on the lumbar and in particular thoracic regions is poorly understood. The aim of this study was to evaluate spinal curvature across the lumbar and thoracic region, and extensor muscle activity during acute micro ...
Anita Meinke, Alessandro Longhi Baez, Niklas Wiesmann, Oliver Ullrich, David A. Green, David A. Green, Marcel Egli, Marcel Egli, Jaap Swanenburg, Jaap Swanenburg   +9 more
doaj   +1 more source

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Lateral retroperitoneal approach for the treatment of a recumbent silkworm-like paravertebral schwannoma in the lumbar spine: a case report

Frontiers in Oncology
ObjectiveThis case report describes the surgical management of a recumbent silkworm-like paravertebral schwannoma in the lumbar spine resected via the lateral retroperitoneal approach.MethodsA lumbar paravertebral schwannoma resembling a “recumbent ...
Lanming Su, Wei Liu, Yingying Zhang, Feng Li, Yuanqin Liu, Ziyu Wang   +5 more
doaj   +1 more source

Circadian‐Inspired Hydrogel Moisture Electricity Generation

Advanced Science, EarlyView.
A circadian‐inspired hydrogel moisture‐electric generator enables sustainable electricity generation by autonomously current direction switching between daytime and nighttime. This reversible output is accompanied by inversion of the internal water gradient, which effectively reduce hydrogel fatigue and offers a new strategy for harvesting diurnal ...
Ziqi Li, Dilalanmu Ahemaitijiang, Hongfei Yang, Xuan Zhao, Mengjiao Pan, Jun Wan, Pingan Zhu, Dahua Shou   +7 more
wiley   +1 more source

Primary superior lumbar hernia፡ a rare cause of lumbar swelling

, 2019
Alemayehu Gonie Mekonnen,1 Kebebe Bekele Gonfa2 1Department of Nursing, College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia; 2Department of Surgery, School of Medicine, Goba Referral Hospital, Madda Walabu University, Bale-Goba ...
Gonfa KB, Mekonnen AG
core  

Association Between Lumbar Disc Herniation and Vertebral Endplate Modic Changes: An MRI-Based Study

Advanced Biomedical Research
Background: Low back pain (LBP) is a prevalent health concern with various causes, including lumbar disc herniation (LDH) and vertebral endplate Modic changes (MCs).
Pegah Torabi, Ghazaleh Jamalipour Soufi, Ali Hekmatnia, Hadi Ravanbod, Mehdi Teimouri, Mahdi Shahsavan, Farzaneh Hekmatnia, Mohammad Shahsavan   +7 more
doaj   +1 more source