Results 121 to 130 of about 441,593 (257)

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Survival ability of deciduous trees in the clearings in stands of black pine (Pinus nigra Arnold) in the Karst region [PDF]

, 2020
V diplomski nalogi se je ugotavljalo, katere drevesne vrste bi bile primerne za premene malodonosnih kraških gozdov. V prvem letu po saditvi so bili preverjeni deleži preživetja sadik, višina sadik ter njihov prirastek in vitalnost.
Lumbar, Andrej
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Comparison of lumbar fusion surgery with/without isobar device among patients with lumbar spine degeneration [PDF]

, 2018
1.Lumbar fusion surgery with ISOBAR device and PLIF surgery both can reduce back pain & disability for patients with lumbar degenerations patients. 2.Lumbar fusion surgery with ISOBAR device had better efficacy in reducing back pain & disability than the
Wu, Meng-Shan, Su, Shu-Fen
core   +1 more source

Hypoglossal and lumbar motor neuron death in old Sprague–Dawley rats

Physiological Reports
Striated muscle weakness and motor neuron (MN) death are associated with aging. These alterations affect both brainstem and spinal motor pools, including hypoglossal MNs innervating the tongue and lumbar MNs innervating the lower/hindlimbs.
Sang Won Cheung, Laney Bjerke, Debanjali Dasgupta, Gary C. Sieck, Matthew J. Fogarty   +4 more
doaj   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Hallazgos degenerativos de columna lumbar en resonancia magnética de pacientes con dolor lumbar Edgar [PDF]

, 2013
El resumen es una presentación abreviada y precisa (la NTC 1486 de 2008 recomienda Introducción: Entre los padecimientos que mayor impacto genera en la población económicamente activa en todo el mundo se encuentra el dolor lumbar bajo también conocido
González Rodríguez, Edgar Iván
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Artificial Intelligence and Its Impact on the Management of Lumbar Degenerative Pathology: A Narrative Review

Medicina
In this narrative review, we explore the role of artificial intelligence (AI) in managing lumbar degenerative conditions, a topic that has recently garnered significant interest.
Alessandro Trento, Salvatore Rapisarda, Nicola Bresolin, Andrea Valenti, Enrico Giordan   +4 more
doaj   +1 more source

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Biomechanical experimental studies of the lumbar spine under static and dynamic loading conditions

, 2013
During the past decades the number of spinal injuries has increased. Traffic accidents are the cause of more than 50 per cent of these injuries. Fractures and dislocations of the vertebrae as well as minor spinal injuries can cause both acute and chronic
Osvalder, Anna-Lisa,
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