Results 211 to 220 of about 104,993 (291)

Mendelian randomization analysis identifies HLA‐A and AP2M1 as genetic biomarkers linked to immune–endocytic crosstalk in intervertebral disc degeneration

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
HLA‐A and AP2M1 are identified as key endocytosis‐related biomarkers that modulate immune–endocytic crosstalk via mTOR signaling to regulate cell survival, immune infiltration, and the progression of intervertebral disc degeneration. Abstract Intervertebral disc degeneration (IVDD) is a major contributor to chronic spinal disorders, yet the role of ...
Yukui Tian, Xue Bai, Nianrong Han, Cheng Wang, Junchang Liu   +4 more
wiley   +1 more source

Identification of BRAF V600E Mutation in Cerebrospinal Fluid Aids in Diagnosing Leptomeningeal Carcinomatosis Arising From Pleomorphic Xanthoastrocytoma: A Case Report

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Pleomorphic xanthoastrocytomas (PXAs) are rare primary central nervous system (CNS) tumors that appear heterogeneous on imaging and histology and typically cause headaches or seizures on initial presentation. Alongside high rates of favorable prognosis after surgical excision exist similarly high rates of recurrence.
Randy S. D'Amico, Patricia Avancena, Alon Kashanian, Rosivel Galvez, Deborah Gruber, Sami Saba, Avraham Zlochower, Manju Harshan, Morana Vojnic   +8 more
wiley   +1 more source

Zeroing in: achieving zero complications in lumbar puncture - a quality improvement initiative to reduce complications at the University Hospital of North Norway. [PDF]

BMJ Open Qual
Ingebrigtsen SG, Eltoft A, Kilvaer TK.
europepmc   +1 more source

Glymphatic System Dysfunction in Central Nervous System Diseases

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Glymphatic Dysfunction in Neurological Disorders: The glymphatic system is a brain‐wide clearance system that removes neurotoxic waste via AQP4‐mediated CSF‐ISF exchange. Dysfunction through AQP4 mislocalization, BBB injury, and inflammation annihilates clearance and causes acute (stroke, TBI) and chronic disease.
Anwar Zahran, Omar Abu‐Khazneh, Mohammad Bdair, Orabi Hajjeh, Mohammed AbuBaha, Waseem Shehadeh, Ameer Awashra, Ibrahim Alazizi, Raya Fuqha, Sakeena Saife, Hasan Fuqha, Fathi Milhem, Husam Hamshary, Dana Abuzahra, Umar Shuaib   +14 more
wiley   +1 more source

Knowledge, Attitude, and Practice Among Caregivers About Lumbar Puncture in the Pediatric Age Group in the Western Region of Saudi Arabia. [PDF]

Cureus
Nemri AA, Asiri SS, Mansouri FF.
europepmc   +1 more source

Anatomical Localization–Based Analysis of Relapsed Secondary Central Nervous System Aggressive B‐Cell Lymphoma (R‐SCNSL)

Hematological Oncology, Volume 44, Issue 2, March 2026.
ABSTRACT 162 patients with relapsed secondary central nervous system lymphoma (R‐SCNSL) (median age, 65 years; male, 59.9%) including central nervous system (CNS)‐only (n = 120) and concomitant CNS/systemic relapse (n = 42) were retrospectively analyzed.
Izel Okcu, Yucai Wang, Zhuo Li, Launia J. White, Patrick B. Johnston, Allison C. Rosenthal, Jonas Paludo, Rebecca L. King, Thomas E. Witzig, Thomas M. Habermann, Grzegorz S. Nowakowski, Han W. Tun   +11 more
wiley   +1 more source

Lowering the platelet count threshold to 40x10⁹/L for lumbar puncture: can this represent a generalized approach? Comment on: "40 is the new 50: reducing the need for platelet transfusions prior to lumbar puncture in adults with hematologic malignancies". [PDF]

Haematologica
Eşkazan AE.
europepmc   +1 more source

Intrathecal idursulfase‐IT in children younger than 3 years with neuronopathic mucopolysaccharidosis II in a single‐arm, open‐label, phase 2/3 substudy and extension

JIMD Reports, Volume 67, Issue 2, March 2026.
Abstract Data from a phase 2/3, randomized, controlled, open‐label, multicenter trial in children with neuronopathic mucopolysaccharidosis II (MPS II; Hunter syndrome) older than 3 years suggested a benefit of intrathecal idursulfase‐IT on cognitive functioning in some patients. We describe a separate, parallel, open‐label, single‐arm, 52‐week substudy
Joseph Muenzer, Barbara K. Burton, Paul Harmatz, Luis González Gutiérrez‐Solana, Matilde Ruiz‐Garcia, Simon A. Jones, Nathalie Guffon, Michal Inbar‐Feigenberg, Drago Bratkovic, Stewart Rust, Michael Hale, Yuna Wu, Karen S. Yee, David A. H. Whiteman, David Alexanderian   +14 more
wiley   +1 more source

Does Lumbar Puncture Still Have Clinical Value for Patients with Amyotrophic Lateral Sclerosis? [PDF]

Brain Sci
Ginanneschi F, Casali S, Cioni C, Righi D, Emmanuello E, Toccaceli C, Plantone D, De Stefano N.   +7 more
europepmc   +1 more source