Results 41 to 50 of about 45,743 (302)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Transitional, fused and/or supernumerary vertebrae in the lumbosacrocaudal region of the spine - A reality in many domestic mammals

Veterinární Medicína
The aim of this study was to identify the presence of transitional lumbosacral and sacrocaudal vertebrae in domestic mammals, to realise a comparative analysis of the localisation and conformation of this abnormal condition.
C Toader Covasa
doaj   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

The shape of the human lumbar vertebral canal A forma do canal vertebral lombar humano

Arquivos de Neuro-Psiquiatria, 1996
Literature on the anatomy of the human vertebral column characterizes the shape of the lumbar vertebral canal as triangular. The purpose of the present study was to determine the precise shape of the lumbar vertebral canal.
Edmundo Zarzur
doaj   +1 more source

“Head Over Heels” Position of Duodenum-A Unique Congenital Anomaly [PDF]

Journal of Clinical and Diagnostic Research, 2018
Knowledge of congenital anomalies of duodenum and biliary apparatus is useful in radiological diagnosis and surgical procedures of upper abdominal region. We present concurrent variations of duodenum, bile duct and coeliac trunk in this report. The first
Satheesha B Nayak, Sudarshan Surendran, Prakashchandra Shetty, Surekha D Shetty   +3 more
doaj   +1 more source

Characteristics of thoracic and lumbar mobility in patients with degenerative spinal deformity

Di-san junyi daxue xuebao, 2022
Objective To explore the characteristics of thoracic and lumbar mobility in patients with degenerative spine deformity (DSD). Methods A total of 60 patients with degenerative spine deformity (DSD) admitted in our hospital from May 2018 to May 2021 were ...
LI Kai, YANG Sen, YANG Sen, WU Wenjie, YANG Qiankun1, WEI Xiaoyu   +5 more
doaj   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Advanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong, Yi‐Juan Tan, Yan‐Xin Duan, Jing‐Yao Luo, Ming‐Jie Luo, Yi‐Wei Liu, Xin Wang, Yi Luo, Teng‐Fei Wan, Yong Zhou, Zheng‐Guang Wang, Guo‐Wen Hu, Hao Yin, Xin‐Yue Hu, Zhen‐Xing Wang, Ze‐Hui He, Si‐Yi Cheng, Wei Du, Zhe Guan, Hai‐Li Lang, Hong‐Ji Liu, Jia Cao, Peng Chen, Jiang‐Hua Liu, Hui Xie, Chun‐Yuan Chen   +28 more
wiley   +1 more source

Spontaneous derotation of compensatory lumbar curve after thoracic fusion in adolescent idiopathic scoliosis

Spine Surgery and Related Research, 2017
Introduction: Currently, excellent three-dimensional correction can be achieved with use of segmental pedicle screw fixation in adolescent idiopathic scoliosis (AIS). In the majority of patients with major thoracic curves, selective thoracic fusion (STF)
Satoru Demura, Hideki Murakami, Satoshi Kato, Katsuhito Yoshioka, Noritaka Yonezawa, Naoki Takahashi, Hiroyuki Tsuchiya   +6 more
doaj   +1 more source

Posterolateral Migration of Complete Vertebral Body in Neglected Tuberculosis of the Spine

Journal of Orthopedics, Traumatology and Rehabilitation, 2022
The most common presentation of tuberculosis (TB) of the spine is paradiscal lesion secondarily involving adjacent disc and vertebral bodies. If not diagnosed early, it can lead to extensive destruction and atypical features.
Svareen Kaur, Roop Singh, Hemant More, Mohit Khanna   +3 more
doaj   +1 more source