Results 51 to 60 of about 45,743 (302)

PAIN FROM ENLARGEMENT OF LUMBAR VERTEBRA [PDF]

open access: yesThe Journal of Nervous and Mental Disease, 1921
n ...
Nové-Josserand, G., Rendu, A.
openaire   +2 more sources

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu   +11 more
wiley   +1 more source

The practical use of computed tomography in evaluation of shell lesions in six loggerhead turtles (Caretta caretta)

open access: yesVeterinární Medicína, 2016
Six adult loggerhead turtles were found stranded and were rescued near Sicily within a period of 12 months. Macroscopically apparent lesions of the shell were present.
F. Spadola   +4 more
doaj   +1 more source

Efficiency of various options for surgical treatment and prevention of proximal junctional kyphosis in patients with lumbar spine deformities and concomitant osteoporosis

open access: yesХирургия позвоночника, 2022
Objective. To conduct a comparative analysis of the effectiveness of various options for the prevention of proximal junctional kyphosis (PJK) in the surgical treatment of adult patients with deformities of the lumbar spine, including taking into ...
Dmitry A. Ptashnikov   +5 more
doaj   +1 more source

Proximate cause, anatomical correlates, and obstetrical implication of a supernumerary lumbar vertebra in humans

open access: yes, 2017
Objectives: Three issues are considered on variation in number of presacral vertebrae (PSV) in humans: (1) sexual difference in number of PSV, (2) inactivation of Hoxd-11 gene as etiology for a supernumerary lumbar vertebra, and (3) anatomical correlates
Tague, Robert G., Robert G. Tague
core   +1 more source

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

open access: yesAdvanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li   +4 more
wiley   +1 more source

Sacralization of the Fifth Lumbar Vertebra

open access: yes, 2020
Sacralization of the fifth lumbar vertebra, also known as Lumbosacral transitional vertebra (LSTV) (Jancuska et al, 2015), is a common congenital pathology that may affect up to 30% of the population (Alonzo et al, 2018).
Hofland, Samantha
core  

Study on incidence of sacralisation of fifth lumbar vertebra in South Indian population

open access: yes, 2016
The lumbosacral region is of interest because of increased incidence of low back pain resulting from stress and strain. The lumbosacral spine supports and transmits weight of the body to the inferior extremity and thus plays an important role in posture.
Krishnamurthy, Asha   +1 more
core   +1 more source

Wireless, Adaptable and Fully Implantable Battery‐powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents

open access: yesAdvanced Science, EarlyView.
Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh   +8 more
wiley   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

open access: yesAdvanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo   +11 more
wiley   +1 more source

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