Results 241 to 250 of about 35,838 (276)

Chronic, Battery‐Free, Fully Implantable Multimodal Spinal Cord Stimulator for Pain Modulation in Small Animal Models

Advanced Science, Volume 12, Issue 21, June 5, 2025.
This work introduces wireless‐powered fully implantable spinal cord stimulation (SCS) in freely moving animal models, supporting diverse ethological paradigms. kHz stimulation with real‐time digital programming offers versatile, dynamically optimized therapy. Scalable fabrication ensures high N studies and seamless translation.
Allie J. Widman, Taron Bashar, Alex Burton, David Marshall Clausen, Prashant Gupta, Drew K. Wolf, Jakayla Folarin‐Hines, Maria Payne, John A Rogers, Kathleen W. Meacham, Robert W. Gereau, Philipp Gutruf   +11 more
wiley   +1 more source

Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Viridicatol (VDC), isolated from the deep‐sea‐derived fungus, enhances osteogenesis in vitro and in vivo by targeting Wnt/SHN3 signaling pathway. It can be delivered via engineered nanovesicles to mitigate bone loss of osteoporosis, fracture repair, and osteogenesis imperfecta.
Chun‐Lan Xie, Shang‐Hui Ye, Yu‐Ting Yue, Bao‐Hong Shi, Jing‐Ping Xu, Lian‐Jie Li, Zheng‐Biao Zou, Matthew B. Greenblatt, Na Li, Xian‐Wen Yang, Ren Xu   +10 more
wiley   +1 more source

Lumbar and Thoracic Vertebrae Segmentation in CT Scans Using a 3D Multi-Object Localization and Segmentation CNN [PDF]

Xiaofan Xiong, Stephen A. Graves, Brandie Gross, John M. Buatti, Reinhard Beichel   +4 more
openalex   +1 more source

Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun, Yangyang Shi, Chen Yan, Shunmin Wang, Linhui Han, Fudong Li, Ximing Xu, Yuan Wang, Jingchuan Sun, Zijian Kang, Jiangang Shi   +10 more
wiley   +1 more source

Transcription factor GTF2I regulates osteoclast differentiation through mediating miR‐134‐5p and MAT2A expressions

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Abstract This study explored the possible effect of transcription factor GTF2I on the differentiation of osteoclasts and its regulation on the miR‐134‐5p/MAT2A axis. RANKL‐induced osteoclasts were measured for expressions of GTF2I, miR‐134‐5p, and MAT2A. The number and size of osteoclasts were assessed after TRAP staining. The expressions of osteoclast
Lian Tang, Yanshi Liu, Jiyuan Yan, Lin Yuan, Zhaojun Wang, Zhong Li   +5 more
wiley   +1 more source

Optimisation of Intervertebral Disc Mechanical Properties and the Impact of Vertebral Alignment in Subject‐Specific Finite Element Models

International Journal for Numerical Methods in Biomedical Engineering, Volume 41, Issue 6, June 2025.
Optimisation methods were compared for a porcine lumbar intervertebral disc model. Neither optimising with 6‐axis forces and moments nor optimising with disc pressures fully captured spinal behaviour. Addressing model limitations could improve the process.
Emily S. Kelly, Akbar A. Javadi, Timothy P. Holsgrove, Michael Ward, David Williams, Jenny Williams, Cathy Holt, Judith R. Meakin   +7 more
wiley   +1 more source

Normotensive trauma patients with renal injuries: Hidden candidates for massive transfusion

Hong Kong Journal of Emergency Medicine, Volume 32, Issue 3, June 2025.
Abstract Background Early identification of trauma patients requiring massive transfusion (MT) is crucial for improving outcomes. However, current scoring systems may overlook patients with initially stable vital signs who later require MT. This study aimed to identify anatomic risk factors for MT in relatively stable trauma patients upon emergency ...
Xin‐Hong Lin, Pi‐Chieh Lin, Ching‐Hua Tsai, Wei‐Ti Su, Shiun‐Yuan Hsu, Ching‐Hua Hsieh   +5 more
wiley   +1 more source

Myosteatosis as a New Risk Factor of Surgical Complications in Kidney Transplant Recipients: A Retrospective Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Background Computed tomography (CT) scan–defined myosteatosis is a common feature in ESKD patients receiving kidney transplantation (KT) and is associated with mortality after KT. We aimed to explore the impact of myosteatosis and other CT scan based morphometric data on the occurrence of early surgical complications after KT.
Antoine Morel, Yaniss Ouamri, Lauriane Ségaux, Louai Zaidan, Michael Moryoussef, Sébastien Mulé, Cécile Maud Champy, Edouard Reizine, Alexandre Ingels, Alain Luciani, Philippe Grimbert, Florence Canouï‐Poitrine, Marie Matignon, Frédéric Pigneur, Thomas Stehlé   +14 more
wiley   +1 more source

Quantification of Skeletal Muscle at the First Lumbar Level for Prognosis in Amyotrophic Lateral Sclerosis

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Background Skeletal muscle parameters at the first lumbar vertebra (L1) level on computed tomography (CT) are common indicators for muscle mass. However, their relationship with the severity and prognosis of amyotrophic lateral sclerosis (ALS) patients remains unclear.
Yujia Cao, Baoyu Yuan, Xiuyu Jiang, Chunming Xie, Di Wu, Zhijun Zhang   +5 more
wiley   +1 more source

Novel Aptamers Targeting Sclerostin Loop3 Improve Skeletal and Muscle Properties Without Adverse Cardiovascular Effects in Orchiectomized Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 3, June 2025.
ABSTRACT Background The Wnt/β‐catenin pathway and its bone‐specific inhibitor, sclerostin, play important roles in skeletal development and homeostasis. The humanized sclerostin antibody, romosozumab, can significantly increase bone mineral density (BMD) of patients with osteoporosis, but it may also increase cardiovascular adverse events, particularly
Bingna Zhou, Jing Hu, Yuanyuan Yu, Lei Sun, Yanye Wang, Qian Zhang, Yan Jiang, Ou Wang, Xiaoping Xing, Weibo Xia, Luyao Wang, Ge Zhang, Mei Li   +12 more
wiley   +1 more source