Results 71 to 80 of about 199,382 (285)

Compressive load bearing and bone architecture of lumbar vertebrae in terms of sex and aging [PDF]

, 2004
Relation between vertebral compressive strength and trabecular architecture is presented in terms of aging and sex. Complex in vitro medical-engineering analysis of cadaver human lumbar L1 and L2 vertebrae was executed: densitometry, CT, MRI, mechanical ...
Fornet, B., Kurutzné Kovács, Márta, Gálos, M.   +2 more
core   +1 more source

Biomechanical Evaluation of Compressive Stress in Lumbar Vertebrae – A Pilot Survey

National Journal of Clinical Anatomy
Background: Cadaveric research in orthopedics poses challenges for medical students and early-career professionals due to limited resources, mentorship, and technical support.
Alexander Baur, Joseph DiPetto, William Dedmond, Keith Lustig   +3 more
doaj   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Lumbar Spine Location in Fluoroscopic Images by Evidence Gathering

, 2000
Low back pain (LBP) is a very common problem and lumbar segmental instability is one of the causes. It is important to investigate lumbar spine movement in order to understand instability better and as an aid to diagnosis.
Allen, Robert, Nixon, Mark S., Zheng, Yalin   +2 more
core   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Anatomical Evaluation of Lumbar Arteries for Lateral Lumbar Interbody Fusion with Magnetic Resonance Imaging

Spine Surgery and Related Research, 2020
Introduction: Lateral lumbar interbody fusion (LLIF) is becoming a more common surgical treatment option for adult degenerative lumbar conditions. LLIF is a mini-open access technique with wound retractors, and postoperative hematoma due to segmental ...
Masato Kiyohara, Takeshi Arizono, Akihiko Inokuchi, Takahiro Hamada, Kenjiro Nishida, Ryuta Imamura   +5 more
doaj   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

Cumulative occupational lumbar load and lumbar disc disease : results of a German multi-center case-control study (EPILIFT) [PDF]

, 2009
Background The to date evidence for a dose-response relationship between physical workload and the development of lumbar disc diseases is limited. We therefore investigated the possible etiologic relevance of cumulative occupational lumbar load to lumbar
Grifka, Joachim, Ditchen Dirk, Joachim Grifka, Hofmann Friedrich, Martina Michaelis, Ellegast Rolf, Oliver Linhardt, Annekatrin Bergmann, Elsner Gine, Petereit-Haack, Gabriela, Jäger Matthias, Rolf Ellegast, Ditchen, Dirk Marcel, Luttmann, Alwin, Schumann Barbara, Seidler, Andreas, Haerting Johannes, Seidler Andreas, Luttmann Alwin, Jäger, Matthias, Grifka Joachim, Friedrich Hofmann, Schumann, Barbara, Andreas Seidler, Michaelis, Martina, Johannes Haerting, Bergmann, Annekatrin, Alwin Luttmann, Haerting, Johannes, Elsner, Gine, Ulrich Bolm-Audorff, Ellegast, Rolf, Bolm-Audorff, Ulrich, Barbara Schumann, Michaelis Martina, Dirk Ditchen, Hofmann, Friedrich, Petereit-Haack Gabriela, Bolm-Audorff Ulrich, Gine Elsner, Gabriela Petereit-Haack, Ellegast, Rolf Peter, Linhardt Oliver, Ditchen, Dirk, Bergmann Annekatrin, Linhardt, Oliver, Matthias Jäger   +46 more
core   +2 more sources