Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer
Advanced Science, EarlyView.The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu +13 more
wiley +1 more source
Morphometric analysis reveals that the chick cranial neural tube expands as an active shell. [PDF]
Biophys Rep (N Y)Chahare N, Imamura C, Nerurkar NL.
europepmc +1 more source
Advanced Science, EarlyView.Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Qinyao Li +6 more
wiley +1 more source
Endovascular repair of a complicated acute type B aortic dissection in a pediatric patient with visceral and lower-extremity malperfusion. [PDF]
J Vasc Surg Cases Innov TechZielke T +4 more
europepmc +1 more source
Sustainable Materials Design With Multi‐Modal Artificial Intelligence
Advanced Science, EarlyView.Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu +8 more
wiley +1 more source
Isolated Brachiocephalic Artery Dissection after Two-Debranching Thoracic Endovascular Aortic Repair: A Case Report. [PDF]
Ann Vasc DisKemmochi R, Ujihira K, Tokunaga N.
europepmc +1 more source
Engineering Microbial Particles for Next‐Generation Biomedical Platforms
Advanced Science, EarlyView.Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li +7 more
wiley +1 more source
Frozen Elephant Trunk versus Ascyrus Medical Dissection Stent in Acute Type A Aortic Dissection: Choosing the Appropriate Arch Strategy. [PDF]
Aorta (Stamford)Ohri S, Modi A, Asopa S, Tsang G.
europepmc +1 more source
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
True lumen stenting guided by intravascular ultrasound-confirmed wire repositioning from the subintimal space following balloon inflation during intravascular lithotripsy-induced coronary dissection: a case report. [PDF]
Eur Heart J Case RepTokuyama H.
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