Results 121 to 130 of about 19,061 (299)

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

Luminescence analysis of a postglacial landscape in northeastern Norway and northern Finland

Boreas
Portable optically stimulated luminescence (pOSL) analysis allows rapid relative dating of sediments that potentially can be calibrated against known OSL ages to provide an age estimate for landforms across a large area.
Alastair Goodship, Helena Alexanderson, Joanna Anjar   +2 more
doaj   +1 more source

Discrimination of Thermoluminescent Signals from Natural Quartz and Carbonate Crystals Mixture

Crystals
Luminescence techniques, especially thermoluminescence (TL) and optically stimulated luminescence (OSL), are essential for dating materials in Cultural Heritage.
Rosaria Galvagno, Giuseppe Stella, Riccardo Reitano, Anna Maria Gueli   +3 more
doaj   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Electrochemiluminescence Drives Photodynamic Therapy In Vivo

Advanced Science, EarlyView.
Electrochemiluminescence (ECL)‐driven photodynamic therapy (PDT) for in vivo cancer treatment is reported for the first time. The flexible ECL patch exhibits stable and intense luminance under alternating current voltage, enabling efficient photosensitization to generate reactive oxygen species that damage cancer cells, thus leading to significant ...
Jia‐Bao Lin, Ling‐Ling Xu, Yong Liu, Hang Gao, Hong‐Yuan Chen, Jing‐Juan Xu   +5 more
wiley   +1 more source

Determining the Age of Terrace Formation Using Luminescence Dating-A Case of the Yellow River Terraces in the Baode Area, China. [PDF]

Methods Protoc, 2020
Zhang JF, Qiu WL, Hu G, Zhou LP.
europepmc   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Reconstructing Mollisol Formation Processes Through Quantified Pedoturbation

Geophysical Research Letters
Mollisols are highly fertile soils and function as significant carbon reservoirs. However, determining their ages and formation processes is challenging due to extensive pedoturbation, which undermines conventional dating methods.
Aimin Zhang, Hao Long, Fei Yang, Jingran Zhang, Jun Peng, Yonghui Shi, Ganlin Zhang   +6 more
doaj   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

From the Northern Hajar Foothills to the Batinah Coast – a Geoarchaeological Survey at Saham and Dahwa (Northern Oman)

Open Quaternary
This geoarchaeological survey was dedicated to (i) the Umm an-Nar (2700–2000 BCE) settlement site of Dahwa and surrounding areas in the foothills of the Hajar Mountains as well as (ii) the coastal area near Saham on the Batinah coastal plain in northern ...
Max Engel, Anja Zander, Martin Kehl, Gary R. Feulner, Khaled Douglas, Nasser Said Ali Al-Jahwari, Nasser Hamad Al-Hinai, Helmut Brückner   +7 more
doaj   +1 more source