Results 61 to 70 of about 244,442 (332)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Nanophotonics, 2018 Stretchable and self-healing polymer gels with luminescent property are very promising materials for next generation soft optical devices. This work presents the preparation of self-healing and luminescent polymer gels by simply blending organometal ...
Fang Minjie +8 more
doaj +1 more source
Distributed Fiber Voice Sensor Based on Phase-Sensitive Optical Time-Domain Reflectometry
IEEE Photonics Journal, 2015 A fiber-optic phase-sensitive optical time-domain reflectometry ('-OTDR) distributed sensing system has been proposed and demonstrated for human-voice detecting and reproducing applications.
Yuqing Wu +5 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Synthesis of luminescent silicon clusters by spark ablation [PDF]
, 1993 The synthesis of luminescent nanometer-scale Si clusters by spark ablation from a crystalline Si substrate is described. The cluster source, described in the text, generates clusters in a flowing Ar stream at atmospheric pressure.
Atwater, Harry A. +6 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
The thermodynamics of optical étendue
, 2008 The concept of ´etendue is applied to the propagation of luminescent radiation, and to the transformation of such radiation in absorbing and luminescent media.
Markvart, T.
core +1 more source
EPR and Structural Characterization of Water-Soluble Mn2+-Doped Si Nanoparticles. [PDF]
, 2017 Water-soluble poly(allylamine) Mn2+-doped Si (SiMn) nanoparticles (NPs) were prepared and show promise for biologically related applications. The nanoparticles show both strong photoluminescence and good magnetic resonance contrast imaging.
Atkins, Tonya M +6 more
core +3 more sources