Results 31 to 40 of about 77,555 (230)

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Lanthanide(III) complexes of rhodamine-DO3A conjugates as agents for dual-modal imaging [PDF]

, 2013
Two novel dual-modal MRI/optical probes based on a rhodamine-DO3A conjugate have been prepared. The bis aqua-Gd(III) complex Gd.L1 and mono aqua-Gd(III) complex Gd.L2 behave as dual-modal imaging probes (r1 = 8.5 and 3.8 mM-1s-1 for Gd.L1 and Gd.L2 ...
Gallo, Juan, Long, Nicholas J., Minuzzi, Florencia, Rivas, Charlotte, Rutter, Guy A., Stasiuk, Graeme J.   +5 more
core   +2 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

High Open Circuit Voltage Solar Cells based on bright mixed-halide CsPbBrI2 Perovskite Nanocrystals Synthesized in Ambient Air Conditions [PDF]

, 2018
Lead halide perovskite nanocrystals (NCs) are currently emerging as one of the most interesting solution processed semiconductors since they possess high photoluminescence quantum yield (PLQY), and colour tunability through anion exchange reactions or ...
Christodoulou, Sotirios, Konstantatos, Gerasimos, Pradhan, Santanu, Stasio, Francesco Di, Stavrinadis, Alexandros   +4 more
core   +3 more sources

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

FEBS Open Bio, EarlyView.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Claudia Valentina Popa, Simona Ghenea, Ileana Cornelia Farcasanu   +4 more
wiley   +1 more source

Method and apparatus for eliminating luminol interference material [PDF]

, 1979
A method and apparatus for removing porphyrins from a fluid sample which are unrelated to the number of bacteria present in the sample and prior to combining the sample with luminol reagent to produce a light reaction is disclosed.
Jeffers, E. L., Thomas, R. R.
core   +1 more source

Luminescent properties of Bi-doped polycrystalline KAlCl4

, 2012
We observed an intensive near-infrared luminescence in Bi-doped KAlCl4 polycrystalline material. Luminescence dependence on the excitation wavelength and temperature of the sample was studied.
A. A. Veber, A. N. Romanov, AG Okhrimchuk, AN Romanov, AN Romanov, AN Romanov, B Denker, CS Yoo, E. V. Haula, EM Dianov, G Meyer, GP Dong, H-T Sun, H-T Sun, H-T Sun, H-T Sun, HL Davis, I Razdobreev, IA Bufetov, J Ruan, L Su, L Su, L. A. Trusov, LT Bugaenko, M Peng, M Peng, MA Hamstra, MCM Lucas de, MO Ramirez, NJ Bjerrum, O. V. Usovich, P. E. Kazin, V. B. Sulimov, V. B. Tsvetkov, V. N. Korchak, W Jia, WA Runciman, XG Meng, Y Fujimoto, Y Fujimoto, Z. T. Fattakhova   +40 more
core   +1 more source

Surface dose analysis and dosimetric comparison of Halcyon versus Truebeam in breast cancer radiotherapy: An OSL dosimetry study

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Breast cancer is a neoplastic disease with high prevalence among women. Radiotherapy is one of the principal treatment modalities for this disease, but it poses significant challenges. This study aimed to compare and evaluate the technical and dosimetric performance of conventional C‐arm linac systems and a new design, Halcyon, in the ...
Mustafa Çağlar, Kudret Akçay, Esra Serin, Dursun Eşitmez, Mehmet Sıddık Cebe, Navid Kheradmand, Ömer Yazıcı, Dilek Ünal, Evrim Metcalfe   +8 more
wiley   +1 more source

Clinical validation of myOSLchip: A beryllium oxide optically stimulated luminescent dosimeter (OSLD) system in radiotherapy dosimetry

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract In radiation oncology, inter‐fractional dosimetry using optically stimulated luminescent detectors (OSLDs) ensures accurate plan delivery and patient safety. RadPro International GmbH's myOLSchip system, featuring a beryllium oxide (BeO) OSL dosimeter, reader, and eraser, was characterized and calibrated with a Varian Truebeam for in‐vivo ...
Heath Davis, Jeffrey V. Siebers, Krishni Wijesooriya, Matt Mistro   +3 more
wiley   +1 more source