Intelligent Point-of-Care Biosensing Platform Based on Luminescent Nanoparticles and Microfluidic Biochip with Machine Vision Algorithm Analysis. [PDF]
Liu Y+7 more
europepmc +1 more source
Targeting p21‐Positive Senescent Chondrocytes via IL‐6R/JAK2 Inhibition to Alleviate Osteoarthritis
This study uncovers a novel mechanism behind uneven cartilage degeneration in knee osteoarthritis (OA). Elevated IL‐6R expression activates the IL‐6 pathway, leading to SIRT1 degradation, chondrocyte senescence, and reduced SOX9 activity, which impairs cartilage matrix synthesis. Notably, the JAK inhibitor tofacitinib prevents IL‐6R‐mediated senescence,
Xiang Zhao+11 more
wiley +1 more source
<i>Lactobacillus</i> probiotic cell-free supernatants and vitamin D influence interleukin-6 production and mitigate oral periodontopathogens-induced cytotoxicity in FaDu cells. [PDF]
Zanetta P+6 more
europepmc +1 more source
Single Platform for Gene and Protein Expression Analyses Using Luminescent Gold Nanoclusters
Sunil Kumar Sailapu+4 more
openalex +1 more source
The permeability to calcium of pigeon erythrocyte ‘ghosts’ studied by using the calcium-activated luminescent protein, obelin [PDF]
Anthony K. Campbell, Robert L. Dormer
openalex +1 more source
Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function
CYTOR is a pro‐myogenic ncRNA in skeletal muscle. Here, chemical probing of CYTOR, coupled with functional cellular assays identifies exon 2 as an independent myogenic RNA domain. Chemical engineering of CYTOR exon 2 RNA improves pharmacologic properties, including RNA stability and cell‐autonomous immunogenicity.
Zeinabou Niasse‐Sy+6 more
wiley +1 more source
Luminescent sensing of conformational integrin activation in living cells. [PDF]
Villari G+8 more
europepmc +1 more source
Structure and formation of highly luminescent protein-stabilized gold clusters
Daniel M. Chevrier+12 more
openalex +2 more sources
Cloning and sequence analysis of cDNA for the luminescent protein aequorin. [PDF]
S Inouye+7 more
openalex +1 more source