Results 241 to 250 of about 49,910 (293)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Split Reporter Systems in Viral Protein-Protein Interactions and Multimerization: Mechanisms and Applications. [PDF]

Cells
Ahmad H, Masood F, Iqbal U, Shaltout M, Yukselten Y, Sutton RE.   +5 more
europepmc   +1 more source

Molecular mechanism of biocompatible clusteroluminogens from citric acid and l-lysine. [PDF]

RSC Adv
Zhang Q, Sun P, Li B.
europepmc   +1 more source

Interplay between SpaO variants shapes the architecture of the <i>Salmonella</i> type III secretion sorting platform. [PDF]

mBio
Soto JE, Wang T, Galán JE, Lara-Tejero M.   +3 more
europepmc   +1 more source

Targeting GSTZ1 Sensitizes KRASG12C-Mutant Lung Cancer Cells by Overcoming Glutathione and Glycolysis Pathway Rewiring. [PDF]

Cancer Res Commun
Liao Y, Li X, Liu M, Fernandes VC, Duckett D, Haura EB, Monastyrskyi A, Rix U.   +7 more
europepmc   +1 more source

A luminescent reporter assay to quantify SORL1 ectodomain shedding and retromer-dependent endosome recycling activity. [PDF]

J Biol Chem
Fazeli E, Jan A, Huber AK, Jensen AMG, Fazeli E, Klein J, Merchant K, Andersen OM.   +7 more
europepmc   +1 more source

Genetically engineered luminescent proteins in biosensing

SPIE Proceedings, 2006
Luminescent proteins originally isolated from marine or terrestrial organisms have played a key role in the development of several biosensing systems. These proteins have been used in a variety of applications including, immunoassays, binding assays, cell-based sensing, high throughput screening, optical imaging, etc.
Laura Rowe, Mark Ensor, Daniel Scott
exaly   +3 more sources

Luminescent proteins in binding assays

, 2006
The use of light-emitting proteins for the detection of biomolecules provides fast and sensitive methods which overcome the disadvantages of radioactive labels and the high cost of fluorescent dyes. This reference work summarizes modern advanced techniques and their applications and includes practical examples of assays based on photoproteins. The book
RODA, ALDO, GUARDIGLI, MASSIMO, MICHELINI, ELISA, MIRASOLI, MARA, PASINI, PATRIZIA   +4 more
openaire   +3 more sources

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Luminescent spectroscopy of proteins

International Journal of Biochemistry & Cell Biology, 1993
exaly   +4 more sources