Results 31 to 40 of about 402,790 (249)

Practical Knowledge and Luminosity [PDF]

, 2019
Many philosophers hold that if an agent acts intentionally, she must know what she is doing. Although the scholarly consensus for many years was to reject the thesis in light of presumed counterexamples by Donald Davidson, several scholars have recently ...
Glasscock, Juan S. Piñeros
core  

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

The Radio and Gamma-Ray Luminosities of Blazars [PDF]

, 2001
Based on the $\gamma$-ray data of blazars in the third EGRET catalog and radio data at 5 GHz, we studied the correlation between the radio and $\gamma$-ray luminosities using two statistical methods. The first method was the partial correlation analysis method, which indicates that there exist correlations between the radio and $\gamma$-ray ...
arxiv   +1 more source

Mid-infrared luminosity as an indicator of the total infrared luminosity of galaxies

, 2004
The infrared (IR) emission plays a crucial role for understanding the star formation in galaxies hidden by dust. We first examined four estimators of the IR luminosity of galaxies, L_fir (Helou et al. 1988), L_tir (Dale et al.
A. Boselli, Boselli, Boselli, Buat, Buat, Chary, D. Burgarella, Dale, Dale, Dale, Downes, Downes, Dunne, Fang, Franceschini, Galliano, Granato, Helou, Hirashita, Houck, J. Iglesias-Páramo, Lagache, Madden, Papovich, Sanders, Saunders, Spinoglio, T. T. Takeuchi, Takagi, Takeuchi, Takeuchi, Takeuchi, Takeuchi, Takeuchi, Takeuchi, Totani, V. Buat, Xu   +37 more
core   +5 more sources

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

The lag and duration-luminosity relations of gamma-ray burst pulses

, 2010
Relations linking the temporal or/and spectral properties of the prompt emission of gamma-ray bursts (hereafter GRBs) to the absolute luminosity are of great importance as they both constrain the radiation mechanisms and represent potential distance ...
Aloy, Amati, Arimoto, Band, Band, Beloborodov, Daigne, Firmani, Frail, Gehrels, Ghirlanda, Ghirlanda, Ghisellini, Giannos, Golenetskii, Guetta, Hafizi, Hakkila, Hakkila, Kistler, Kouveliotou, Lazar, Liang, M. Hafizi, Narayan, Norris, Norris, Norris, Norris, Porciani, Preece, R. Mochkovitch, Reichart, S. Boçi   +33 more
core   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Redshift indicators for gamma-ray bursts [PDF]

Nuovo Cim.C28:647-652,2005, 2005
The measure of the distances and luminosities of gamma-ray bursts (GRBs) led to the discovery that many GRB properties are strongly correlated with their intrinsic luminosity, leading to the construction of reliable luminosity indicators. These GRB luminosity indicators have quickly found applications, like the construction of 'pseudo-redshifts', or ...
arxiv   +1 more source

Triggering at High Luminosity Colliders

, 2007
This article discusses the techniques used to select online promising events at high energy and high luminosity colliders. After a brief introduction, explaining some general aspects of triggering, the more specific implementation options for well ...
Beck, Hans Peter
core   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source