Results 61 to 70 of about 32,712 (291)
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
The cepheid luminosity scale [PDF]
Space Science Reviews, 1980 The distances of clusters containing classical Cepheids are central to the calibration of the period-luminosity relation. As a step in improving the reliability of the calibration, uvbys photometry was obtained for B stars in eight of these clusters. These data were then used to determine the distances of the clusters and, thus, the absolute magnitudes
openaire +4 more sources
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Temas Agrarios, 2018 Potassium is a macronutrient that can improve the growth of crops. A randomized complete block design was used to evaluate the influence of four planting densities (50,000, 41,667, 33,333, 31,250 plants ha-1) and three potassium levels (300, 250, 200 kg ...
Amanda Silva Parra +2 more
doaj +1 more source
Floresta e Ambiente, 2020 As native tree species are often used for densification, enrichment and degraded areas recovery, a better understanding of the behavior of their seedlings in response to light exposure is needed. This study evaluates the growth and morphological behavior
Alexandre Techy de Almeida Garrett +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel +3 more
wiley +1 more source
Measuring Luminosity at OLYMPUS [PDF]
, 2014 Published by Deutsches Elektronen-Synchrotron, DESY ...
openaire +2 more sources
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose This study aims to develop a CycleGAN based denoising model to enhance the quality of low‐dose PET (LDPET) images, making them as close as possible to standard‐dose PET (SDPET) images. Methods Using a Philips Vereos PET/CT system, whole‐body PET images of fluorine‐18 fluorodeoxyglucose (18F‐FDG) were acquired from 37 patients to ...
Yang Liu, ZhiWu Sun, HaoJia Liu
wiley +1 more source
Revista Facultad Nacional de Agronomía Medellín, 2011 Obtener estándares del color del fruto de café durante su desarrollo y maduración es necesario para diferentes procesos relacionados con la cosecha y poscosecha de este producto.
José Jaime Carvajal Herrera +3 more
doaj