Results 141 to 150 of about 2,005,645 (268)

Association between dynamic digital radiography findings and post-extubation respiratory deterioration: A retrospective exploratory analysis of a prospectively collected ICU cohort. [PDF]

PLoS One
Komatsu S, Nishida K, Hara Y, Kuriyama N, Nakamura T.   +4 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

The human lung microbiome progressively diminishes in the distal alveolar regions. [PDF]

NPJ Biofilms Microbiomes
Potratz P, Häder A, Kursawe L, Kikhney J, Gaßler N, Lauf T, Radosa L, Sandhaus T, von Samson P, Chen X, Wang L, Brakhage AA, Moter A, Panagiotou G, Doenst T, Deinhardt-Emmer S, Löffler B.   +16 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Lobar-level radiomic clustering reveals background lung changes associated with lung cancer risk: a new perspective for early screening. [PDF]

Insights Imaging
Wang Y, Zhu C, Lu Z, Zhou X, Lin C, Li Y, Shi L, Wu L, Ma H, Zhu M, Chen J, Lv J, Zhu L, Du L, Ji C, Ren H, Wang E, Shi L.   +17 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Sex-related differences in lung injury distribution and outcomes in COVID-19 acute respiratory failure: insights from the CT-COVID19 multicenter study group. [PDF]

Intensive Care Med Exp
Signori D, Nova A, Xin Y, Gerard SE, Magliocca A, Vitale G, Mussoni L, Montomoli J, Subert M, Ponti A, Spadaro S, Poli G, Casola F, Garberi R, Restivo A, Raimondi Cominesi D, Giani M, Zambelli V, Foti G, Laffey JG, Cereda M, Rezoagli E, CT-COVID19 Multicenter Study Group.   +22 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Usual Interstitial Pneumonia in a Patient With Celiac Disease: Expanding the Spectrum of Pulmonary Manifestations. [PDF]

Respirol Case Rep
Gopagoni R, Fayyaz H, Tazelaar H, Sonavane S, Balasubramanian P, Krishna M, Bag R.   +6 more
europepmc   +1 more source

LUNG

Journal of Cancer Research and Therapeutics
openaire   +2 more sources