Results 121 to 130 of about 989,686 (264)

EGFR exon 20 insertion in lung adenocarcinomas among hispanics (geno1.2-CLICaP)

, 2018
Objectives Contrasting other EGFR mutations (EGFRm) in lung adenocarcinomas, insertions in exon 20 (exon20ins) are generally associated with resistance to targeted therapy, limiting therapeutic options and impoverishing the prognosis compared to other ...
Carranza, Hernán, Zatarain-Barrón, Zyanya Lucia, Castillo, Omar, Otero, Jorge, Wills, Beatriz, Acosta Madiedo, José, de Lima, Vladimir, Cardona-Mendoza, Andrés Felipe, Arrieta, Oscar, Archila, Pilar, Granados, Sara T., Vargas Báez, Carlos Alberto, González, Lisde, Pérez, María Angelina, Rodriguez, Jenny, Ruiz-Patiño, Alejandro, Lema, Mauricio, Rojas Puentes, Leonardo, Karachaliu, Niki, Rodríguez Ariza, July Katherine, Martín, Claudio, Corrales, Luis, Freitas, Helano C., Oblitas, George, Chirinos, Luis, Rosell, Rafael, Pino, Luis E., Castro, Christian D.   +27 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Prognostic value of hTERT mRNA expression in surgical samples of lung cancer patients : the European Early Lung Cancer Project

, 2010
Lung cancer is the most important cause of cancer-related mortality. Resectability and eligibility for treatment with adjuvant chemotherapy is determined by staging according to the TNM classification.
Heideman, Danielle A.M., Sozzi, Gabriella, Elborn, J. Stuart, Postmus, Pieter E., O'Byrne, Ken J., Martinet, Yves, Niklinski, Jacek, Sutedja, G. Thomas, Smit, Egbert F., Becker, Heinrich D., Van Den Berg, Remco M., Brambilla, Christian, Montuenga, Luis M., Meijer, Chris J.L.M., Snijders, Peter J.F., Brokx, Hes, Field, John K., Vesin, Aurelien, Risch, Angela, Thunnissen, Frederick B., Harrison, David J.   +20 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Pulmonary neuroendocrine cells: crucial players in respiratory function and airway-nerve communication

Frontiers in Neuroscience
Pulmonary neuroendocrine cells (PNECs) are unique airway epithelial cells that blend neuronal and endocrine functions, acting as key sensors in the lung.
Abhimanyu Thakur, Abhimanyu Thakur, Shuya Mei, Shuya Mei, Noel Zhang, Kui Zhang, Kui Zhang, Boghos Taslakjian, Jiacee Lian, Shuang Wu, Shuang Wu, Bohao Chen, Julian Solway, Huanhuan Joyce Chen, Huanhuan Joyce Chen   +14 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Lung

, 1992
Performance in the B. Iden Payne Theatre (UT-Austin). Choreography by Yacov Sharir (The Egg), Jose Luis Bustamante (Lung). See full record (link below) for more details.Theatre and Dance46 minutes: 21 minutes/25 minutes.
Sharir Dance Company
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Quantification of lung glucose metabolism with positron emission tomography in patients with Acute Lung Injury [PDF]

, 2011
Acute lung injury is lung pathologies that confer considerable morbidity and high mortality and has no specific treatment. One cause of ALI exacerbation can be the mechanical ventilation provided in the intensive care unit ICU probably because of ...
Grecchi, Elisabetta
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source