Results 111 to 120 of about 989,686 (264)

Aspergillus and the Lung

Seminars in Respiratory and Critical Care Medicine
AbstractThe filamentous fungus Aspergillus causes a wide spectrum of diseases in the human lung, with Aspergillus fumigatus being the most pathogenic and allergenic subspecies. The broad range of clinical syndromes that can develop from the presence of Aspergillus in the respiratory tract is determined by the interaction between host and pathogen.
Janssens, Iris, Lambrecht, Bart, Van Braeckel, Eva   +2 more
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formation. [PDF]

, 2012
Treatment of acute lung injury (ALI) remains an unsolved problem in intensive care medicine. As simvastatin exerts protective effects in inflammatory diseases we explored its effects on development of ALI and due to the importance of neutrophils in ALI ...
Vijayan, Santosh, Mörgelin Matthias, Grommes Jochen, Köppel, Thomas, Grommes, Jochen, Binneboesel, Marcel, Mörgelin, Matthias, Helene Hartwig (158829), Weber, Christian, Matthias Mörgelin (109607), Rolf Dembinski, Santosh Vijayan, Jochen Grommes (158815), Söhnlein, Oliver, Dembinski, Rolf, Drechsler, Maik, Thomas Andreas Koeppel, Oliver Soehnlein, Moergelin, Matthias, Vijayan Santosh, Dembinski Rolf, Weber Christian, Santosh Vijayan (158820), Koeppel, Thomas Andreas, Binnebösel, Marcel, Christian Weber (86566), Maik Drechsler (158824), Michael Jacobs, Maik Drechsler, Lund University., Rolf Dembinski (12675), Thomas Andreas Koeppel (158847), Koeppel Thomas Andreas, Marcel Binnebösel, Matthias Mörgelin, Jacobs, Michael, Jacobs Michael, Binnebösel Marcel, Oliver Soehnlein (158864), Michael Jacobs (105163), Hartwig Helene, Jochen Grommes, Mörgelin, Matthias,, Helene Hartwig, Marcel Binnebösel (158855), Soehnlein, Oliver, Hartwig, Helene, Drechsler Maik, Soehnlein Oliver, Christian Weber   +49 more
core   +2 more sources

Scoring of swine lung images: a comparison between a computer vision system and human evaluators

Veterinary Research
Cranioventral pulmonary consolidation (CVPC) is a common lesion observed in the lungs of slaughtered pigs, often associated with Mycoplasma (M.) hyopneumoniae infection. There is a need to implement simple, fast, and valid CVPC scoring methods. Therefore,
Robert Valeris-Chacin, Beatriz Garcia-Morante, Marina Sibila, Albert Canturri, Isaac Ballarà Rodriguez, Ignacio Bernal Orozco, Ramon Jordà Casadevall, Pedro Muñoz, Maria Pieters   +8 more
doaj   +1 more source

Differentiation of early-stage tumors from benign lesions manifesting as pure ground-glass nodule: a clinical prediction study based on AI-derived quantitative parameters

Frontiers in Oncology
ObjectivesDifferentiating between benign and malignant pure ground-glass nodule (pGGN) is of great clinical significance. The aim of our study was to evaluate whether AI-derived quantitative parameters could predict benignity versus early-stage tumors ...
Shuxiang Chen, Huijuan Zhang, Yifan Chen, Shuo Chen, Wenfu Cao, Yongxiu Tong   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The association between blood coagulation activity and lung function: a population-based study [PDF]

, 2010
<p><b>Background:</b> Increased in susceptibility to thrombotic disease may be associated with lower lung function. If causal, this association may suggest an area for development of new interventions for lung disease.
Lowe, G.D.O., Lorna Clark, Clark, L., Sarah A Lewis, Andrew W Fogarty, Tricia M McKeever, John Britton, Fogarty, A.W., Lewis, S.A., Gordon D O Lowe, Britton, J., Sarah A. Lewis, McKeever, T.M., Gordon D. O. Lowe, Tricia M. McKeever, Reitsma, P.H., Andrew W. Fogarty   +16 more
core   +2 more sources

ASSESSMENT OF REQUIREMENT OF THE POPULATION IN THE ORGAN TRANSPLANTATION, THE DONOR RESOURCE AND PLANNING OF THE EFFECTIVE NETWORK OF THE MEDICAL ORGANIZATIONS (THE CENTERS OF TRANSPLANTATION)

Вестник трансплантологии и искусственных органов, 2013
Aim. To estimate the requirement of the population of the Russian Federation for an organ transplantation and donor resource, to offer approach to planning of an effective network of the medical organizations (the centers of transplantation).
S. V. Gautier, S. M. Khomyakov
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source