Results 91 to 100 of about 989,686 (264)

Platelet-activating factor receptor plays a role in lung injury and death caused by influenza A in mice [PDF]

, 2010
Influenza A virus causes annual epidemics which affect millions of people worldwide. A recent Influenza pandemic brought new awareness over the health impact of the disease.
Sousa, Lirlandia P., Garcia, Cristina C., Remo C Russo, Salgado, Ana Paula C., Geovanni D. Cassali, Mauro M. Teixeira, Tavares, L.P., Polidoro, Rafael B., Caio T Fagundes, Luciana P Tavares, Tavares, Luciana P., Machado, A.V., Salgado, Ana Paula Carneiro, Rodrigo Guabiraba, Garcia, C.C., Russo, R.C., Cristiana C Garcia, Guabiraba Brito, R., Remo C. Russo, Alexandre V Machado, Machado, Alexandre Vieira, Polidoro, Rafael Barbosa, Caio T. Fagundes, Cassali, Geovanni D., Teixeira, Mauro Martins, Cassali, Geovanni Dantas, Mauro M Teixeira, Lirlândia P. Sousa, Fagundes, C.T., Salgado, A.P.C., Ana Paula C. Salgado, Cassali, G.D., Garcia, Cristiana Couto, Russo, Remo de Castro, Russo, Remo C., Rafael B. Polidoro, Sousa, L.P., Teixeira, M.M., Ana Paula C Salgado, Alexandre V. Machado, Rafael B Polidoro, Machado, Alexandre V., Fagundes, Caio T., Guabiraba, Rodrigo, Cristiana C. Garcia, Polidoro, R.B., Lirlândia P Sousa, Sousa, Lirlândia Pires de, Geovanni D Cassali, Luciana P. Tavares, Teixeira, Mauro M., Salgado, Ana Paula C, Tavares, Luciana P, Machado, Alexandre V, Polidoro, Rafael B, Cassali, Geovanni D, Teixeira, Mauro M, Sousa, Lirlândia P, Garcia, Cristiana C, Russo, Remo C, Fagundes, Caio T   +60 more
core   +2 more sources

Comprehensive genomic profiling of combined small cell lung cancer

, 2021
Background: Combined small cell lung cancer (CSCLC) is an uncommon and heterogeneous subtype of small cell lung cancer (SCLC). However, there is limited data concerning the different molecular changes and clinical features in CSCLC compared to pure SCLC.
Jiang, Gening, Zhang, Peng, Goto, Taichiro, Wu, Chunyan, Cardona, Andrés F., Chen, Qiankun, Zhang, Liping, Zhu, Yuming, Hou, Likun, Yu, Huansha, Zhang, Jing, Santarpia, Mariacarmela, Malhotra, Jyoti, Luo, Jie, Troncone, Giancarlo, Sun, Liangdong, Okuda, Katsuhiro, Li, Junqiang, Fan, Pengyu, Wu, Chunxiao, Zamarchi, Rita, Xu, Jianfang, Zhang, Zhonghong, Ge, Tao   +23 more
core   +1 more source

Intersections of lung progenitor cells, lung disease and lung cancer [PDF]

European Respiratory Review, 2017
The use of stem cell biology approaches to study adult lung progenitor cells and lung cancer has brought a variety of new techniques to the field of lung biology and has elucidated new pathways that may be therapeutic targets in lung cancer. Recent results have begun to identify the ways in which different cell populations interact to regulate ...
openaire   +5 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Chronic rhinoviral infection in lung transplant recipients [PDF]

, 2006
RATIONALE: Lung transplant recipients are particularly at risk of complications from rhinovirus, the most frequent respiratory virus circulating in the community.
Yerly, Sabine, Meylan, P., Letovanec, I., Letovanec, Igor, Deffernez, C., Soccal, P.M., Aubert, J.D., Pache, Jean-Claude, Kaiser, L., Rochat, T., Aubert, J.-D., Meylan, Pascal, Tapparel, C., Pache, J.-C., Garbino, J., Rochat, Thierry, Deffernez, Christelle, Perrin, L., Pache, J.C., Kaiser, Laurent, Nicod, Laurent, Aubert, John-David, Tapparel, Caroline, Aubert, J. D., Wunderli, Werner, Gasche-Soccal, Paola Marina Alessandra, Nicod, L., Yerly, S., Garbino, Jorge, Yerly Ferrillo, Sabine, Soccal, Paola M, Wunderli, W., Perrin, Luc   +32 more
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Biomaterials for in vitro models in lung research

, 2022
In this chapter we introduce biomaterials science to a nonexpert reader in order to provide new perspectives for the development of in vitro three-dimensional models that are relevant in lung research. Specifically, we provide a comprehensive description
Elowsson, Linda,, Ibáñez-Fonseca, Arturo,, Lund University.   +2 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A randomised non-comparative phase II study of atezolizumab, bevacizumab and chemotherapy in EGFR-mutant NSCLC with acquired resistance - The ETOP 15-19 ABC-lung trial.

ABC-lung explores the potential effect of combining atezolizumab and bevacizumab with either carboplatin/paclitaxel (ABCPac) or pemetrexed (ABPem) in patients with EGFR-mutant NSCLC, resistant to tyrosine kinase inhibitors (TKIs).
Garcia Campelo, R., Ruepp, B., Vervita, K., Moran, T., Britschgi, C., Cho, B.C., Callejo, A., Dafni, U., Roschitzki-Voser, H., Haberecker, M., Addeo, A., Ortega Granados, A.L., Blasco, A., Früh, M., Sala González, M.A., Gasca-Ruchti, A., Reck, M., Ribi, K., Soo, R.A., Provencio, M., Peters, S., Domine Gomez, M., Majem, M., Rodriguez Abreu, D., Han, J.Y., Stahel, R.A.   +25 more
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Polymorphisms of CYP1A1 I462V and GSTM1 genotypes and lung cancer susceptibility in Mongolian [PDF]

, 2009
Aim: To study the genotype of cytochrome P450 1A1(CYP1A1) I462V and glutathions S-transferase M1( GSTM1) and the relationship of the genetic polymorphism of them with the susceptibility of lung cancer in Mongolia of China.
Guang Wang, Zhi-Xie Zhang, Qin Yin, Jia Ma, Fuhou Chang, Min-jie Wang, Jun QI   +6 more
core  

Analysis of lung surfactant phosphatidylcholine metabolism in transgenic mice using stable isotopes [PDF]

, 2011
Stable isotope labelling of lipid precursors coupled with mass spectrometry-based lipidomic analyses and determination of isotope enrichment in substrate, intermediate and product pools provide the parameters needed to determine absolute flux rates ...
Grielof Koster, Koster, G., Howard W. Clark, Clark, Howard, Anthony D. Postle, Neil G. Henderson, Henderson, N.J., Alan N. Hunt, Postle, A.D., Hunt, A.N.   +9 more
core   +1 more source