Results 81 to 90 of about 2,954,568 (313)

Patient-reported outcomes with durvalumab, with or without tremelimumab, plus chemotherapy as first-line treatment for metastatic non-small-cell lung cancer (POSEIDON)

, 2023
Objectives: In the phase 3 POSEIDON study, first-line tremelimumab plus durvalumab and chemotherapy significantly improved overall survival and progression-free survival versus chemotherapy in metastatic non-small-cell lung cancer (NSCLC).
Mann, H., Lim, F.L., Garon, E.B., Saito, H., Farah Louise Lim, Alexander Luft, Melissa Johnson, Edward B Garon, Johnson, M., Xiaojin Shi, Tony Mok, Maen Hussein, Medic, N., Mok, T., Nenad Medic, Cho, B.C., Cheng-Ta Yang, Jorge Alatorre-Alexander, Solange Peters, Geater, S.L., Araujo, L.H., Grygorii Ursol, Luiz Henrique Araujo, Sang-We Kim, Helen Mann, Shi, X., Reinmuth, N., Yang, C.T., Luft, A., Niels Reinmuth, Haruhiro Saito, Byoung Chul Cho, Peters, S., Ursol, G., Kim, S.W., Alatorre-Alexander, J., Hussein, M., Sarayut Lucien Geater   +37 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Exploring the incidence of lung cancer in small areas across Scotland [PDF]

, 2015
Lung cancer is one of the most important causes of 'avoidable deaths' globally and is responsible for approximately 900,000 deaths per year. However, lung cancer rates tend to be higher for males than for females and the disease also varies ...
Pearce, James R,
core   +1 more source

Comparison of three Radiotherapy Techniques Volumetric Modulated Arc Therapy with Variable and Constant Dose Rate and Intensity-Modulated Radiotherapy for the Irradiation of Five Cancer Sites [PDF]

Journal of Biomedical Physics and Engineering
Background: Volumetric modulated arc therapy (VMAT) is mostly considered due to its superior tumor coverage and sparing of organs at risk (OAR) with shorter treatment delivery time.Objective: This study aimed to explore the feasibility and potential ...
Varsha Raghunathji Gedam, Anirudh Pradhan   +1 more
doaj   +1 more source

Lung transplantation [PDF]

Clinical Medicine, 1995
The last 30 years have seen lung transplantation grow from a procedure associated with absolute failure to one which now offers excellent outcomes for patients with advanced lung disease. It has brought much needed hope and is truly a remarkable story of medical advancement in the field of respiratory medicine.
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Newfoundland Lung Association Newsletter; Lung Association of Newfoundland and Labrador Newsletter

, 1982
The Northern Light, Summer 1982Contents Page -- The Cross of Lorraine or Double-Barred Cross -- Obituaries -- Editorial: 1982, A Year to Remember / E. G. House -- His Hon. W. Anthony Paddon, C.M. M.D.
Newfoundland Lung Association
core  

Prognostic value of hTERT mRNA expression in surgical samples of lung cancer patients : the European Early Lung Cancer Project

, 2010
Lung cancer is the most important cause of cancer-related mortality. Resectability and eligibility for treatment with adjuvant chemotherapy is determined by staging according to the TNM classification.
Heideman, Danielle A.M., Sozzi, Gabriella, Elborn, J. Stuart, Postmus, Pieter E., O'Byrne, Ken J., Martinet, Yves, Niklinski, Jacek, Sutedja, G. Thomas, Smit, Egbert F., Becker, Heinrich D., Van Den Berg, Remco M., Brambilla, Christian, Montuenga, Luis M., Meijer, Chris J.L.M., Snijders, Peter J.F., Brokx, Hes, Field, John K., Vesin, Aurelien, Risch, Angela, Thunnissen, Frederick B., Harrison, David J.   +20 more
core   +1 more source

12-0-Tetradecanoyl phorbol-13-acetate induced differentiation in human lung squamous carcinoma cells. [PDF]

, 1992
Three human lung squamous carcinoma cell lines (NX002, CX140 and CX143) demonstrate features of squamous differentiation including involucrin synthesis and competence to form cornified envelopes.
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core   +1 more source