Study of biomarkers to determine severity and lung damages in COVID-19 patients
Introduction: Identifying inflammation and lung damage markers is crucial in reducing morbidity and mortality of coronavirus disease 2019 (COVID-19). This study aimed to examine the validity and reliability of severity and post-infection lung damage and
Alfian Nur Rosyid +8 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
The importance of lung microenvironment
A microenvironment is an area with a specific composition of mainly extracellular matrix (ECM) components surrounding the cells. The tight interactions between matrix molecules and cells are very important, and it is now well known that the ECM ...
Malmström, Anders,, Lund University.
core +1 more source
THE TREATMENT EFFECT OF OXYTETRACYCLINE AND VITAMIN C IN AN EPISODE OF PARAINFLUENZA SHEEP IN TIMIS COUNTY [PDF]
Sheep parainfluenza It is a disease with high diffusibility, sometimes with fatal serious, especially youth. It is caused by parainfluenza 3 virus (PI-3), identical to the bovine parainfluenza virus isolate, in combination with certain bacteria.
Stancu, A
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Comparison of three Radiotherapy Techniques Volumetric Modulated Arc Therapy with Variable and Constant Dose Rate and Intensity-Modulated Radiotherapy for the Irradiation of Five Cancer Sites [PDF]
Background: Volumetric modulated arc therapy (VMAT) is mostly considered due to its superior tumor coverage and sparing of organs at risk (OAR) with shorter treatment delivery time.Objective: This study aimed to explore the feasibility and potential ...
Varsha Raghunathji Gedam +1 more
doaj +1 more source
The last 30 years have seen lung transplantation grow from a procedure associated with absolute failure to one which now offers excellent outcomes for patients with advanced lung disease. It has brought much needed hope and is truly a remarkable story of medical advancement in the field of respiratory medicine.
openaire +2 more sources
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Aerosolized BC-819 inhibits primary but not secondary lung cancer growth. [PDF]
Despite numerous efforts, drug based treatments for patients suffering from lung cancer remains poor. As a promising alternative, we investigated the therapeutic potential of BC-819 for the treatment of lung cancer in mouse tumor models.
Corinna Pfeifer +26 more
core +2 more sources

