Results 71 to 80 of about 2,638,123 (318)

Evidence supporting a role for circulating macrophages in the regression of vascular remodeling following sub‐chronic exposure to hemoglobin plus hypoxia

Pulmonary Circulation, 2021
Macrophages are a heterogeneous population with both pro‐ and anti‐inflammatory functions play an essential role in maintaining tissue homeostasis, promoting inflammation under pathological conditions, and tissue repair after injury.
Vijaya Karoor, Delaney Swindle, David I Pak, Julie Harral, Derek Strassheim, Mehdi A Fini, Edward Dempsey, Kurt R Stenmark, Kathryn Hassell, Rachelle Nuss, Paul W. Buehler, David C. Irwin   +11 more
doaj   +1 more source

Comprehensive genomic profiling of combined small cell lung cancer

, 2021
Background: Combined small cell lung cancer (CSCLC) is an uncommon and heterogeneous subtype of small cell lung cancer (SCLC). However, there is limited data concerning the different molecular changes and clinical features in CSCLC compared to pure SCLC.
Jiang, Gening, Zhang, Peng, Goto, Taichiro, Wu, Chunyan, Cardona, Andrés F., Chen, Qiankun, Zhang, Liping, Zhu, Yuming, Hou, Likun, Yu, Huansha, Zhang, Jing, Santarpia, Mariacarmela, Malhotra, Jyoti, Luo, Jie, Troncone, Giancarlo, Sun, Liangdong, Okuda, Katsuhiro, Li, Junqiang, Fan, Pengyu, Wu, Chunxiao, Zamarchi, Rita, Xu, Jianfang, Zhang, Zhonghong, Ge, Tao   +23 more
core   +1 more source

Lung transplantation [PDF]

Clinical Medicine, 1995
The last 30 years have seen lung transplantation grow from a procedure associated with absolute failure to one which now offers excellent outcomes for patients with advanced lung disease. It has brought much needed hope and is truly a remarkable story of medical advancement in the field of respiratory medicine.
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice

, 2009
The study aim was to establish how recruitment maneuvers (RMs) influence lung mechanics and to determine whether RMs produce lung injury. Healthy BALB/c mice were allocated to receive positive end-expiratory pressure (PEEP) at 2 or 6 cmH2O and volume ...
Sly, P.D., Hantos, Z, Sly, Peter D., Berry, L.J., Turner, D.J., Zosky, G R, Cannizzaro, V; https://orcid.org/, Turner, Debra J., Hantos, Zoltan, Cannizzaro, V., Berry, Luke J., Nicholls, P.K., Hantos, Z., Nicholls, P K, Sly, P D, Zosk, G.R., Zosky, Graeme R., Berry, L J, Cannizzaro, Vincenzo, Nicholls, Phillip K., Turner, D J   +20 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Study of biomarkers to determine severity and lung damages in COVID-19 patients

Journal of Infection in Developing Countries
Introduction: Identifying inflammation and lung damage markers is crucial in reducing morbidity and mortality of coronavirus disease 2019 (COVID-19). This study aimed to examine the validity and reliability of severity and post-infection lung damage and
Alfian Nur Rosyid, Arina Dery Puspitasari, Wiwin Is Effendy, Herley Windo Setiawan, Arief Bakhtiar, Isnin Anang Marhana, Anggraini Dwi Sensusiati, Jusak Nugraha, Muhammad Amin   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mechanisms of Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia

, 2009
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects preterm infants. Increased levels of inflammatory mediators in the amniotic fluid and in the lungs of preterm infants are associated with the development of BPD.
Hogmalm, Anna
core  

Interstitial lung disease in Malta [PDF]

, 2012
Aim: To establish the prevalence, management and response to treatment of interstitial lung disease (ILD) in Malta. Methodology: The personal files of 102 living and 26 deceased patients with ILD under the care of 4 respiratory physicians were reviewed ...
Fenech, Manwel, Gouder, Caroline, Montefort, Stephen   +2 more
core