Results 51 to 60 of about 989,686 (264)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The Beta Agonist Lung Injury TrIal (BALTI) : prevention trial protocol [PDF]

, 2011
Background: Acute lung injury complicates approximately 25-30% of subjects undergoing oesophagectomy. Experimental studies suggest that treatment with beta agonists may prevent the development of acute lung injury by decreasing inflammatory cell ...
Matthew W Cooke, Thickett, David R, Cooke, MW, Lamb, S. E. (Sallie E.), Thickett David R, David R Thickett, Cooke, Matthew (Professor of clinical systems design), Lamb, Sarah E, Gao, F, Perkins, Gavin D., Gates, S, Daniel Park, Mistry Dipesh, Alderson, D, Fang Gao, Gao, Fang; id_orcid, Alderson, Derek, Cooke Matthew W, Gao Fang, Mistry, D, Dipesh Mistry, Alderson Derek, Perkins, GD, Gao, Fang, Mistry, Dipesh, Park, Daniel P., Park Daniel, Cooke, Matthew W, Thickett, David R; id_orcid, Thickett, DR, Gates, Simon, Lamb, Sarah, Sarah E Lamb, Park, Daniel, Gavin D Perkins, Park, D, Perkins, Gavin D, Simon Gates, Thickett, David R., Smith, F. Gao (Fang Gao), Gates Simon, Lamb Sarah E, Derek Alderson, Perkins Gavin D, Lamb, SE   +44 more
core   +3 more sources

Hyponatremia as a “red flag” for concurrent meningitis in pulmonary cryptococcosis: a risk stratification model

BMC Neurology
Background Pulmonary cryptococcosis (PC) is increasingly diagnosed in human immunodeficiency virus (HIV)-negative and apparently immunocompetent individuals.
Bich-Ngoc T. Nguyen, Hoang-Anh Nguyen-Cong, Mai-Anh Nguyen, Minh-Phuong Duong, Thi-Chang Hoang, Van-Luong Dinh   +5 more
doaj   +1 more source

White Tea Intake Abrogates Markers of Streptozotocin-Induced Prediabetes Oxidative Stress in Rat Lungs’

Molecules, 2021
Prediabetes (PrDM) is a prodromal stage of diabetes mellitus (DM) with an increasing prevalence worldwide. During DM progression, individuals gradually develop complications in various organs.
Ana C. Silveira, Luís Rato, Pedro Fontes Oliveira, Marco G. Alves, Branca M. Silva   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The impact of cytomegalovirus coinfection on tuberculosis in the mouse model

BMC Infectious Diseases
Background Tuberculosis (TB) remains a major global health challenge, with 10.6 million new cases and 1.3 million deaths annually. HIV coinfection is a well-known risk factor in high-burden regions, but emerging evidence suggests that other viral ...
Jaqueline Marschner, Sebastian Marwitz, Lars Eggers, Linda von Borstel, Lara Buer, David Hertz, Torsten Goldmann, Eleonore Ostermann, Wolfram Brune, Bianca E. Schneider   +9 more
doaj   +1 more source

CD8 T cells promote heart failure progression in mice with preexisting left ventricular dysfunction

Frontiers in Immunology
IntroductionEven under the standard medical care, patients with left ventricular (LV) failure or heart failure (HF) often progress to pulmonary hypertension and right ventricular (RV) hypertrophy.
Dongzhi Wang, Dongzhi Wang, Xinyu Weng, Xinyu Weng, Wenhui Yue, Linlin Shang, Linlin Shang, Yidong Wei, John S. Clemmer, Yawei Xu, Yingjie Chen, Yingjie Chen   +11 more
doaj   +1 more source

Systems Biology and Bile Acid Signalling in Microbiome-Host Interactions in the Cystic Fibrosis Lung

Antibiotics, 2021
The study of the respiratory microbiota has revealed that the lungs of healthy and diseased individuals harbour distinct microbial communities. Imbalances in these communities can contribute to the pathogenesis of lung disease. How these imbalances occur
David F. Woods, Stephanie Flynn, Jose A. Caparrós-Martín, Stephen M. Stick, F. Jerry Reen, Fergal O’Gara   +5 more
doaj   +1 more source

The effect of lung biopsy on lung function in diffuse lung disease [PDF]

European Respiratory Journal, 2000
The aim of this study was to investigate the effect on lung function of lung biopsy used in the diagnosis of diffuse lung disease carried out by an open procedure or by video-assisted thoracoscopy. One hundred and sixteen patients with diffuse lung disease who attended the Royal Brompton Hospital were studied retrospectively.
Z, Daniil, F C, Gilchrist, S J, Marciniak, P, Pantelidis, P, Goldstraw, U, Pastorino, R M, du Bois   +6 more
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source