Results 101 to 110 of about 989,686 (264)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Lung

, 1973
A presentation slide reflecting an illustration of the Lungs, and labeled Life Science Flight Research Approach, Sub Subsystems Tissue culture and Cells ...

core  

Evaluation of bexarotene (Targretin (R)) in combination with cisplatin and vinorelbine in chemotherapy-naive patients with advanced stage IIIb/IV non-small cell lung cancer (NSCLC)

, 2005
Great Poland Lung Dis Ctr, Poznan, PolandUniversidade Federal de São Paulo, São Paulo, BrazilMed Univ Gdansk, Gdansk, PolandPavlov State Med Univ, St Petersburg, RussiaMeir Hosp, Inst Oncol, Kefar Sava, IsraelLigand Pharmaceut Inc, San Diego, CA ...
Negro-Vilar, A., Ramlau, R., Hao, D., Gottfried, M., Zatloukal, P., Mabry, M., Tadokoro, H., Jassem, J., Orlov, S., Dziewanowska, Z.   +9 more
core   +1 more source

Spontaneous peristaltic airway contractions propel lung liquid through the bronchial tree of intact and fetal lung explants [PDF]

, 2000
Spontaneous contractions of the fetal airways are a well recognized but poorly characterized phenomenon. In the present study spontaneous narrowing of the airways was analyzed in freshly isolated lungs from early to late gestation in fetal pigs and ...
Schittny, Johannes C., Miserocchi, Giuseppe, Sparrow, Malcolm P.   +2 more
core   +2 more sources

Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond

Frontiers in Medicine
High-throughput technologies in human and animal studies have revealed novel molecular and cellular pathways involved in tissue inflammation of rheumatoid arthritis (RA).
Elpida Neofotistou-Themeli, Elpida Neofotistou-Themeli, Panagiota Goutakoli, Panagiota Goutakoli, Theodoros Chanis, Theodoros Chanis, Maria Semitekolou, Maria Semitekolou, Eirini Sevdali, Eirini Sevdali, Prodromos Sidiropoulos, Prodromos Sidiropoulos   +11 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Risk of development of brain metastases according to the IASLC/ATS/ERS lung adenocarcinoma classification in locally advanced and metastatic disease

, 2021
Introduction: Brain metastases (BM) are frequent among lung cancer patients, affecting prognosis and quality of life. The International Association for the Study of Lung Cancer (IASLC), American Thoracic Society (ATS) and European Respiratory Society ...
Caballé Pérez, Enrique, Escamilla, Ixel, Pereira García, Ariana, Díaz-García, Diego, Lara-Mejía, Luis, Rolfo, Christian Diego, Estuardo Raez, Luis, Avilés Salas, Alejandro, Costa Rosell, Rafael, Arrieta, Oscar, Cardona, Andrés Felipe   +10 more
core   +1 more source

Insights into the Multidisciplinary Approach for Metastatic Acinic Cell Lung Carcinoma: The Pathologist’s Role in Romania Today

Current Oncology
Background/Objectives: Acinic cell carcinoma (ACC) is a rare lung neoplasm that can affect both children and adults as a parenchymal or endobronchial mass.
Dorela-Codruta Lazureanu, Amelia Burlea, Robert Barna, Daniela Cipu, Mihaela Pasca Fenesan, Ioan Icma, Marioara Cornianu   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Chronic fetal hypoxia and antenatal Vitamin C exposure differentially regulate molecular signalling in the lung of female lambs in early adulthood

Frontiers in Physiology
IntroductionChronic fetal hypoxia is commonly associated with fetal growth restriction and can predispose to respiratory disease at birth and in later life. Antenatal antioxidant treatment has been investigated to overcome the effects of oxidative stress
Erin V. McGillick, Erin V. McGillick, Sandra Orgeig, Beth J. Allison, Kirsty L. Brain, Melanie R. Bertossa, Stacey L. Holman, Ashley S. Meakin, Michael D. Wiese, Youguo Niu, Nozomi Itani, Katie L. Skeffington, Christian Beck, Kimberly J. Botting-Lawford, Janna L. Morrison, Janna L. Morrison, Dino A. Giussani   +16 more
doaj   +1 more source