Results 101 to 110 of about 2,638,123 (318)

HTR4 gene structure and altered expression in the developing lung [PDF]

, 2013
Background: Meta-analyses of genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) spanning the 5-hydroxytryptamine receptor 4 (5-HT4R) gene (HTR4) associated with lung function. The aims of this study were to i)
Swan, Caroline, Swan, C, Hodge, Emily, Ian P Hall, Stewart, Ceri E., Ceri E Stewart, Melén, Erik, Nelson, CP, Carl P Nelson, Catherine Gowland, Erik Melén, Henry, Amanda P., Sayers, Ian, Hodge, E, Henry, AP, Sayers, I, Hall, IP, Emily Hodge, Amanda P Henry, Hall, Ian P., Billington, Charlotte K., Anders Malarstig, Malarstig, Anders, Suzanne Miller, Miller, Suzanne, Billington, CK, Gowland, C, Mel�n, Erik, Gowland, Catherine, Stewart, CE, Miller, S, Caroline Swan, Malarstig, A, Melén, E, Nelson, Carl P., Charlotte K Billington, Ian Sayers   +36 more
core   +1 more source

Intersections of lung progenitor cells, lung disease and lung cancer [PDF]

European Respiratory Review, 2017
The use of stem cell biology approaches to study adult lung progenitor cells and lung cancer has brought a variety of new techniques to the field of lung biology and has elucidated new pathways that may be therapeutic targets in lung cancer. Recent results have begun to identify the ways in which different cell populations interact to regulate ...
openaire   +5 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Quantification of lung glucose metabolism with positron emission tomography in patients with Acute Lung Injury [PDF]

, 2011
Acute lung injury is lung pathologies that confer considerable morbidity and high mortality and has no specific treatment. One cause of ALI exacerbation can be the mechanical ventilation provided in the intensive care unit ICU probably because of ...
Grecchi, Elisabetta
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond

Frontiers in Medicine
High-throughput technologies in human and animal studies have revealed novel molecular and cellular pathways involved in tissue inflammation of rheumatoid arthritis (RA).
Elpida Neofotistou-Themeli, Elpida Neofotistou-Themeli, Panagiota Goutakoli, Panagiota Goutakoli, Theodoros Chanis, Theodoros Chanis, Maria Semitekolou, Maria Semitekolou, Eirini Sevdali, Eirini Sevdali, Prodromos Sidiropoulos, Prodromos Sidiropoulos   +11 more
doaj   +1 more source

EGFR exon 20 insertion in lung adenocarcinomas among hispanics (geno1.2-CLICaP)

, 2018
Objectives Contrasting other EGFR mutations (EGFRm) in lung adenocarcinomas, insertions in exon 20 (exon20ins) are generally associated with resistance to targeted therapy, limiting therapeutic options and impoverishing the prognosis compared to other ...
Carranza, Hernán, Zatarain-Barrón, Zyanya Lucia, Castillo, Omar, Otero, Jorge, Wills, Beatriz, Acosta Madiedo, José, de Lima, Vladimir, Cardona-Mendoza, Andrés Felipe, Arrieta, Oscar, Archila, Pilar, Granados, Sara T., Vargas Báez, Carlos Alberto, González, Lisde, Pérez, María Angelina, Rodriguez, Jenny, Ruiz-Patiño, Alejandro, Lema, Mauricio, Rojas Puentes, Leonardo, Karachaliu, Niki, Rodríguez Ariza, July Katherine, Martín, Claudio, Corrales, Luis, Freitas, Helano C., Oblitas, George, Chirinos, Luis, Rosell, Rafael, Pino, Luis E., Castro, Christian D.   +27 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Insights into the Multidisciplinary Approach for Metastatic Acinic Cell Lung Carcinoma: The Pathologist’s Role in Romania Today

Current Oncology
Background/Objectives: Acinic cell carcinoma (ACC) is a rare lung neoplasm that can affect both children and adults as a parenchymal or endobronchial mass.
Dorela-Codruta Lazureanu, Amelia Burlea, Robert Barna, Daniela Cipu, Mihaela Pasca Fenesan, Ioan Icma, Marioara Cornianu   +6 more
doaj   +1 more source

Factors contributing to the time taken to consult with symptoms of lung cancer: a cross-sectional study [PDF]

, 2009
<b>Objectives</b>: To determine what factors are associated with the time people take to consult with symptoms of lung cancer, with a focus on those from rural and socially deprived areas.
Ziebland, S.B., Raja, A, Ziebland, Susan, Duff, EM, MacLeod, U., Ziebland, S. B., Wyke, S, Lee, A. J., Smith, SM, Nicolson, MC, Smith, S.M., Wyke, S., Campbell, N. C., Duff, E.M., Ritchie, L. D., Campbell, N.C., Nicolson, M.C., Lee, AJ, Lee, A.J., Nicolson, M. C., Smith, S. M., Duff, E. M., Ritchie, L.D., Raja, A., MacLeod, U, Ritchie, LD, Campbell, NC   +26 more
core   +1 more source