Results 101 to 110 of about 2,211,257 (305)

Mechanism of DERL3 Affecting the Proliferation, Invasion and Metastasis of Lung Adenocarcinoma A549 Cells

Chinese Journal of Lung Cancer, 2020
Background and objective Derlin 3 (DERL3) is downregulated in colorectal cancer (CRC) samples. Its level is closely linked to lymphatic metastasis or distant metastasis rate in CRC patients.
Dandan ZHOU, Jiemin WANG, Ke YANG, Liping ZHANG, Quan ZHENG, Jun BAI, Yaqiong HU, Qingjie MU, Chonggao YIN, Hongli LI   +9 more
doaj   +1 more source

TRIM2 directly deubiquitinates and stabilizes Snail1 protein, mediating proliferation and metastasis of lung adenocarcinoma

Cancer Cell International, 2020
Background Lung adenocarcinoma has surpassed lung squamous cell carcinoma as the most common type of non-small cell lung cancer. In this study, we had tested the biological role of TRIM2 in lung adenocarcinoma. Methods TRIM2 abundance in clinical tissues
Zhaoxian Lin, Xing Lin, Lihuan Zhu, Jianyuan Huang, Yangyun Huang   +4 more
doaj   +1 more source

LKB1 and KEAP1/NRF2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence in KRAS-mutant lung adenocarcinoma.

Cancer Research, 2019
In KRAS-mutant lung adenocarcinoma, tumors with LKB1 loss (KL) are highly enriched for concurrent KEAP1 mutations, which activate the KEAP1/NRF2 pathway (KLK).
Ana Galán-Cobo, P. Sitthideatphaiboon, Xiao Qu, A. Poteete, M. Pisegna, P. Tong, Pei-Hsuan Chen, Lindsey K. Boroughs, Mirna L. M. Rodriguez, Winter Zhang, F. Parlati, Jing Wang, V. Gandhi, F. Skoulidis, R. Deberardinis, J. Minna, J. Heymach   +16 more
semanticscholar   +1 more source

The distinctive nature of adenocarcinoma of the lung

OncoTargets and Therapy, 2015
In recent years, many personalized treatments have been developed for NSCLC (non-small-cell lung cancer) patients. Among these, gefitinib, erlotinib, and afatinib are selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors for patients with EGFR gene mutations, while crizotinib and ceritinib are two new tyrosine kinase inhibitors ...
openaire   +6 more sources

Expression and clinical role of in lung adenocarcinoma

Journal of International Medical Research
Objective To explore the levels of expression and clinical role of peroxiredoxin 6 ( PRDX6 ) in lung adenocarcinoma. Methods This retrospective study used a series of bioinformatics methods to detect the levels of expression of and mutations in the PRDX6
Zixin Chen, Junjun Lin, Huifang Wang, Jing Wang, Zhou Zhang   +4 more
doaj   +1 more source

Hmga2 is dispensable for pancreatic cancer development, metastasis, and therapy resistance. [PDF]

, 2018
Expression of the chromatin-associated protein HMGA2 correlates with progression, metastasis and therapy resistance in pancreatic ductal adenocarcinoma (PDAC). Hmga2 has also been identified as a marker of a transient subpopulation of PDAC cells that has
Chiou, Shin-Heng, Dorsch, Madeleine, Grüner, Barbara M, Koong, Albert C, Kozak, Margaret M, Kusch, Eva, Naranjo, Santiago, Winslow, Monte M   +7 more
core   +1 more source

Widespread rash in lung adenocarcinoma

ESMO Open, 2018
A 68-year-old man is being treated with cisplatin-pemetrexed in the first line for bone metastatic lung adenocarcinoma. There is partial response and very good tolerance with no grade 3–4 toxicities. After six cycles of doublet therapy, the patient follows on pemetrexed maintenance. Six months later, he develops a hot and itchy rash with …
José Miguel Jurado, Fernando Gálvez-Montosa, Francisco Almazan   +2 more
openaire   +2 more sources

Impact of histopathological subtypes on invasive lung adenocarcinoma: from epidemiology to tumour microenvironment to therapeutic strategies

World Journal of Surgical Oncology
Lung adenocarcinoma is the most prevalent type of lung cancer, with invasive lung adenocarcinoma being the most common subtype. Screening and early treatment of high-risk individuals have improved survival; however, significant differences in prognosis ...
Shaowei Xin, Miaomiao Wen, Yahui Tian, Honghong Dong, Zitong Wan, Suxin Jiang, Fancheng Meng, Yanlu Xiong, Yong Han   +8 more
doaj   +1 more source

Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity [PDF]

, 2016
BACKGROUND: Lung cancer is the leading cause of cancer related deaths and Malignant Pleural Effusion (MPE) is a frequent complication. Current therapies suffer from lack of efficacy in a great percentage of cases, especially when cancer is diagnosed at ...
CHERUBINI, EMANUELA, DE VITIS, CLAUDIA, Fabiana Fosca Ferrara, Francesca Bergantino, Francesca Fenizia, Gennaro Ciliberto, GIARNIERI, Enrico, GIOVAGNOLI, Maria Rosaria, Luigi Aurisicchio, MANCINI, RITA, MARIOTTA, Salvatore, Matilde Lambiase, Nicola Normanno, NOTO, ALESSIA, RICCI, Alberto, ROSCILLI, GIUSEPPE, Susan Costantini, TORRISI, Maria Rosaria   +17 more
core   +3 more sources

Genomic and immune profiling of pre-invasive lung adenocarcinoma

Nature Communications, 2019
Adenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms of lung adenocarcinoma. The genomic and immune profiles of these lesions are poorly understood.
Haiquan Chen, Jian Carrot-Zhang, Yue Zhao, Haichuan Hu, S. Freeman, Su-Huan Yu, G. Ha, Alison M. Taylor, Ashton C. Berger, Lindsay C. Westlake, Yuanting Zheng, Jiyang Zhang, A. Ramachandran, Q. Zheng, Yunjian Pan, Difan Zheng, Shanbo Zheng, Chao Cheng, Muyu Kuang, Xiaoyan Zhou, Yang Zhang, Hang Li, T. Ye, Yuan Ma, Zhendong Gao, Xiaoting Tao, Han Han, Jun Shang, Ying Yu, Ding Bao, Yechao Huang, Xiangnan Li, Ya-wei Zhang, J. Xiang, Yihua Sun, Yuan Li, A. Cherniack, Joshua D. Campbell, Leming Shi, M. Meyerson   +39 more
semanticscholar   +1 more source