Results 101 to 110 of about 2,251,685 (405)

Expression and clinical role of in lung adenocarcinoma

Journal of International Medical Research
Objective To explore the levels of expression and clinical role of peroxiredoxin 6 ( PRDX6 ) in lung adenocarcinoma. Methods This retrospective study used a series of bioinformatics methods to detect the levels of expression of and mutations in the PRDX6
Zixin Chen, Junjun Lin, Huifang Wang, Jing Wang, Zhou Zhang   +4 more
doaj   +1 more source

Genomic and immune profiling of pre-invasive lung adenocarcinoma

Nature Communications, 2019
Adenocarcinoma in situ and minimally invasive adenocarcinoma are the pre-invasive forms of lung adenocarcinoma. The genomic and immune profiles of these lesions are poorly understood.
Haiquan Chen, Jian Carrot-Zhang, Yue Zhao, Haichuan Hu, S. Freeman, Su-Huan Yu, G. Ha, Alison M. Taylor, Ashton C. Berger, Lindsay C. Westlake, Yuanting Zheng, Jiyang Zhang, A. Ramachandran, Q. Zheng, Yunjian Pan, Difan Zheng, Shanbo Zheng, Chao Cheng, Muyu Kuang, Xiaoyan Zhou, Yang Zhang, Hang Li, T. Ye, Yuan Ma, Zhendong Gao, Xiaoting Tao, Han Han, Jun Shang, Ying Yu, Ding Bao, Yechao Huang, Xiangnan Li, Ya-wei Zhang, J. Xiang, Yihua Sun, Yuan Li, A. Cherniack, Joshua D. Campbell, Leming Shi, M. Meyerson   +39 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

HLA-G Expression in Lung Adenocarcinoma Tissues and Its Relationship with Prognosis

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the expression of HLA-G and determine the prognostic value of HLA-G for lung adenocarcinoma. Methods The genomic alternation of HLA-G was analyzed using cBioPortal analytic tool.
ZHANG Wenlong, ZHANG Panpan, SI Jiahui, MA Yuanyuan, YANG Yue   +4 more
doaj   +1 more source

Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Electronic-cigarette smoke (ECS) is designed to deliver nicotine, and its use is gaining popularity. Previously, we found that ECS induces DNA damage and inhibits DNA repair in the mouse lungs and bladder urothelium.
M. Tang, Xue-Ru Wu, Hyun-wook Lee, Yong Xia, F. Deng, A. Moreira, Lung-Chi Chen, W. Huang, H. Lepor   +8 more
semanticscholar   +1 more source

Identification of a Hypoxia-Associated Signature for Lung Adenocarcinoma

Frontiers in Genetics, 2020
Background A hypoxia microenvironment plays a role in the initiation and progression of many cancer types, but its involvement in lung adenocarcinoma is still unclear.
Zhuomao Mo, Ling Yu, Zhirui Cao, Hao Hu, Shaoju Luo, Shijun Zhang   +5 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

KLF5 facilitates lung adenocarcinoma metastasis by regulating the epithelial-mesenchymal transition pathway through RHPN2

Journal of Translational Medicine
Background Distant metastasis is a primary factor contributing to the significantly shorter survival time of patients with advanced lung adenocarcinoma.
Tao Zhang, Ruo-qi Wang, Yu-bin Yang, Wen-jun Zhao, Qi-dong Zhang, Xu-li Ma, Juan-juan Guo, Qian Su, Xiao-yun Shen, Yong-bin Lu, Fei Su, Xiao-ming Hou   +11 more
doaj   +1 more source

A33 shows similar sensitivity to but is more specific than CDX2 as an immunomarker of colorectal carcinoma [PDF]

, 2017
Aims: CDX2 is widely used as a sensitive and specific immunomarker for colorectal carcinoma (CRC) but neither this sensitivity nor specificity is absolute. This study is the first known comparison of CDX1 and A33 against CDX2 as immunomarkers for CRC.
Adamczyk, Lukasz A., Cullen, Jayne, Evans, Shanna, Oien, Karin A., Oniscu, Anca, Wong, Newton A.C.S.   +5 more
core   +1 more source

KRT6A Promotes EMT and Cancer Stem Cell Transformation in Lung Adenocarcinoma

Technology in Cancer Research and Treatment, 2020
Aim: Keratin 6A is a type II cytokeratin which is important in forming nail bed, filiform papillae, the epithelial lining of oral mucosa, and esophagus; recently, keratin 6A was found hyperexpressed in different types of cancer.
Bing-fen Yang, Wei Zhang, Meng-meng Zhang, Xuhong Wang, S. Peng, R. Zhang   +5 more
semanticscholar   +1 more source