Results 111 to 120 of about 2,211,257 (305)

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer [PDF]

, 2017
KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper understanding of the molecular mechanisms triggered by KRAS oncogene may yield alternative ...
Andersen, Jesper B., Arricibita, Andrea, Bailey, Peter, Biankin, Andrew, Bozec, Aline, Chang, David K., Chuang, Chen-Hua, Guembe, Laura, Guruceaga, Elisabet, Gwinn, Dana, Khatri, Purvesh, Lecanda, Fernando, Martinez-Canarias, Susana, Mazur, Pawel K., Perurena, Naiara, Ponz-Sarvise, Mariano, Sage, Julien, Sayles, Leanne C., Sweet-Cordero, E. Alejandro, Valencia, Karmele, Vallejo, Adrian, Vicent, Silve, Zandueta, Carolina   +22 more
core   +3 more sources

Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Electronic-cigarette smoke (ECS) is designed to deliver nicotine, and its use is gaining popularity. Previously, we found that ECS induces DNA damage and inhibits DNA repair in the mouse lungs and bladder urothelium.
M. Tang, Xue-Ru Wu, Hyun-wook Lee, Yong Xia, F. Deng, A. Moreira, Lung-Chi Chen, W. Huang, H. Lepor   +8 more
semanticscholar   +1 more source

Absence of an embryonic stem cell DNA methylation signature in human cancer. [PDF]

, 2019
BackgroundDifferentiated cells that arise from stem cells in early development contain DNA methylation features that provide a memory trace of their fetal cell origin (FCO). The FCO signature was developed to estimate the proportion of cells in a mixture
Christensen, Brock C, Kelsey, Karl T, Koestler, Devin C, Salas, Lucas A, Wiencke, John K, Zhang, Ze   +5 more
core  

An Immune-Related Signature Predicts Survival in Patients With Lung Adenocarcinoma

Frontiers in Oncology, 2019
We investigated the local immune status and its prognostic value in lung adenocarcinoma. In total, 513 lung adenocarcinoma samples from TCGA and ImmPort databases were collected and analyzed.
Minghui Zhang, Kaibin Zhu, H. Pu, Zhuozhong Wang, Hongli Zhao, Jin-feng Zhang, Yan Wang   +6 more
semanticscholar   +1 more source

USP4 promotes proliferation and metastasis in human lung adenocarcinoma

Scientific Reports
Research the expression of USP4 in lung adenocarcinoma and its correlation with clinicopathological features and prognosis analysis, to explore the invasion and metastasis mechanism of USP4 in lung adenocarcinoma, and to clarify the mechanism of USP4’s ...
Yamin Wei, Shanwang Wei, Zhongteng Lei, Yan Zhang, Jinxiao Wu, Jinli Huang, Lijuan Fu, Zhimeng Li, Guiying Huang, Yuanna Liang, Jinhua Zheng   +10 more
doaj   +1 more source

Lung adenocarcinoma originates from retrovirus infection of proliferating type 2 pneumocytes during pulmonary post-natal development or tissue repair [PDF]

, 2011
Jaagsiekte sheep retrovirus (JSRV) is a unique oncogenic virus with distinctive biological properties. JSRV is the only virus causing a naturally occurring lung cancer (ovine pulmonary adenocarcinoma, OPA) and possessing a major structural protein that ...
A Giangreco, A Harris, A Ortin, A Winkelmann, AB Bahnson, AD Miller, AL Payne, AS Zolotukhin, B Chessa, BB Zhou, BJ Bradley, C Cousens, C Johnson, CF Kim, CG Plopper, Claudio Murgia, D Salvatori, DG Miller, DI Nisbet, DW Verwoerd, E Beytut, EL Rawlins, EL Rawlins, F Arnaud, F Arnaud, F Schwenter, G Zavala, Gabriella Di Francesco, H Fan, JA Platt, JA Whitsett, JC DeMartini, JE Donello, JE Visvader, JM Coffin, JM Sharp, JM Sharp, JP Scheerlinck, K McGee-Estrada, K McGee-Estrada, K McGee-Estrada, K Perk, K Quade, L Naldini, LH Rosai JaS, M Bray, M Caporale, M Caporale, M Caporale, M De Las Heras, M De las Heras, M Palmarini, M Palmarini, M Palmarini, M Palmarini, M Palmarini, M Palmarini, M Palmarini, M Palmarini, M Palmarini, Marcelo de las Heras, Marco Caporale, Massimo Palmarini, MF Clarke, MH Kubbutat, Michael Emerman, MJ Holland, N Maeda, N Maeda, N Maeda, N Rosenberg, Nicola Ferri, Ousman Ceesay, P Banerjee, PF Lewis, RM Dakessian, RP Hill, S Zaffran, SK Rai, SK Rai, SK Wootton, SK Wootton, SL Kauffman, SL Liu, SL Liu, SL Liu, SL Liu, T Reya, T Roe, TB Zeltner, TB Zeltner, TE Allen, U O'Doherty, Vincenzo Varasano   +93 more
core   +6 more sources

Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma

Clinical Cancer Research, 2016
Purpose: Although clinical studies have shown promise for targeting programmed cell death protein-1 (PD-1) and ligand (PD-L1) signaling in non–small cell lung cancer (NSCLC), the factors that predict which subtype patients will be responsive to ...
Z. Dong, W. Zhong, Xuchao Zhang, J. Su, Z. Xie, S. Liu, H. Tu, Hua-jun Chen, Yue-Li Sun, Qing Zhou, Jin-Ji Yang, Xue-Ning Yang, Jia-Xin Lin, Hong-Hong Yan, Hao-ran Zhai, Li-xu Yan, R. Liao, Si-pei Wu, Yi-long Wu   +18 more
semanticscholar   +1 more source

FAP-α is an effective tool to evaluate stroma invasion of lung adenocarcinoma

Diagnostic Pathology
The main difficulty in the diagnosis of atypical in situ adenocarcinoma lies in the distinction between true and false stromal invasion. Moreover, how to identify local alveolar wall collapse in situ lung adenocarcinoma and how to identify whether the ...
Siping Xiong, Huan Fan, Yimin Guo, Ruixiang Sun, Hongmei Ma, Yali Xiang, Chao Zeng   +6 more
doaj   +1 more source

Computational purification of individual tumor gene expression profiles leads to significant improvements in prognostic prediction. [PDF]

, 2013
Tumor heterogeneity is a limiting factor in cancer treatment and in the discovery of biomarkers to personalize it. We describe a computational purification tool, ISOpure, to directly address the effects of variable normal tissue contamination in clinical
Boutros, Paul C, Cui, Ang, Deshwar, Amit G, Haider, Syed, Morris, Quaid, Quon, Gerald   +5 more
core   +2 more sources

Identification and validation of novel DNA methylation markers for early diagnosis of lung adenocarcinoma

Molecular Oncology, 2020
Lung cancer has the highest mortality of all cancers worldwide. Epigenetic alterations have emerged as potential biomarkers for early diagnosis of various cancer tissue types. To identify methylation markers for early diagnosis of lung adenocarcinoma, we
Miao Li, Chen Zhang, Lijun Zhou, Siyu Li, Yuan Jie Cao, Longlong Wang, Rong Xiang, Yi Shi, Yongjun Piao   +8 more
doaj   +1 more source