Results 201 to 210 of about 2,251,685 (405)
STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma.
Cancer Discovery, 2018 F. Skoulidis, M. Goldberg, D. Greenawalt, M. Hellmann, M. Awad, J. Gainor, A. Schrock, R. Hartmaier, S. Trabucco, L. Gay, Siraj M. Ali, J. Elvin, G. Singal, J. Ross, D. Fabrizio, P. Szabo, Han Chang, A. Sasson, S. Srinivasan, S. Kirov, J. Szustakowski, P. Vitazka, R. Edwards, J. Bufill, N. Sharma, S. Ou, N. Peled, D. Spigel, H. Rizvi, E. J. Aguilar, B. Carter, J. Erasmus, D. Halpenny, A. Plodkowski, N. Long, M. Nishino, W. Denning, Ana Galán-Cobo, Haifa Hamdi, Taghreed Hirz, P. Tong, Jing Wang, J. Rodriguez-Canales, P. Villalobos, E. Parra, N. Kalhor, L. Sholl, J. Sauter, A. Jungbluth, M. Mino‐Kenudson, Roxana Azimi, Y. Elamin, Jianjun Zhang, G. Leonardi, F. Jiang, Kwok-kin Wong, J. Lee, V. Papadimitrakopoulou, I. Wistuba, V. Miller, G. Frampton, J. Wolchok, A. Shaw, P. Jänne, P. Stephens, C. Rudin, W. Geese, L. Albacker, J. Heymach +68 moresemanticscholar +1 more sourceDe Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems
Advanced Science, EarlyView.EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.Hind Abdo, Leonardo Barzaghi, Yuan Shen, Edoardo Bellini, Emanuele Martini, Serena Magni, Sara Barozzi, Fabrizio Orsenigo, Dario Parazzoli, Galina V. Beznoussenko, Jasmin Di Franco, Fabian Krautgasser, Jasmin Kaivola, Mario Cinquanta, Alessandro Lazzarin, Sara Sigismund, Johanna Ivaska, Roberto Cerbino, Giorgio Scita +18 morewiley +1 more sourceProteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
Cell, 2020 Michael A. Gillette, S. Satpathy, Song Cao, S. Dhanasekaran, S. Vasaikar, Karsten Krug, F. Petralia, Y. Li, Wen-Wei Liang, B. Reva, R. Hong, Sara R. Savage, G. Getz, Q. Li, Bing Zhang, H. Rodriguez, Kelly V. Ruggles, A. Robles, K. Clauser, R. Govindan, Pei Wang, A. Nesvizhskii, L. Ding, D. Mani, S. Carr +24 moresemanticscholar +1 more sourceRetinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity
Advanced Science, EarlyView.Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan +25 morewiley +1 more sourceLactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian +16 morewiley +1 more sourceIntegrative Proteomic Characterization of Human Lung Adenocarcinoma
Cell, 2020 Junming Xu, Chunchao Zhang, Xiang Wang, Linhui Zhai, Yiming Ma, Y. Mao, Kun Qian, Changqing Sun, Zhiwei Liu, Shangwen Jiang, Minghui Wang, Lin Feng, Lei Zhao, Ping Liu, Bo Wang, Xin Zhao, Hui Xie, Xiaoyun Yang, Liyuan Zhao, Yafei Chang, Jin-hui Jia, Xijun Wang, Yimin Zhang, Yaru Wang, Yikun Yang, Zhixiang Wu, Longhai Yang, Bin Liu, Teng Zhao, Shengguo Ren, A. Sun, Yang Zhao, W. Ying, Fei Wang, Guangshun Wang, Yi Zhang, Shujun Cheng, J. Qin, X. Qian, Yi Wang, Jing Li, F. He, T. Xiao, Minjia Tan +43 moresemanticscholar +1 more sourcePositive Feedback Loop of Histone Lactylation‐Driven HNRNPC Promotes Autophagy to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance
Advanced Science, EarlyView.Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...Xi‐Tai Huang, Jiao Chen, En‐Liang Zhu, Ming‐Jian Ma, Yang‐Yin‐Hui Yu, Ying‐Qin Zhu, Jing‐Yuan Ye, Jin‐Zhao Xie, Zi‐Yi Zhao, Xiao‐Yu Yin +9 morewiley +1 more sourcePreoperative neutrophil-to-lymphocyte ratio (preNLR) for the assessment of tumor characteristics in lung adenocarcinoma patients with brain metastasis
, 2022 Huanhuan Cui, Yuechao Yang, Mingtao Feng, Yang Gao, Liangdong Li, Wenjing Tu, Xin Chen, Bin Hao, Sen Li, Deheng Li, Lei Chen, Changshuai Zhou, Yiqun Cao +12 moreopenalex +1 more source
