Results 231 to 240 of about 2,251,685 (405)

Folic Acid‐Modified Ginger‐Derived Exosome‐Like Nanoparticles Co‐Delivering Sunitinib Suppress Renal Cell Carcinoma via PI3K‐Akt Pathway Inhibition, P‐gp Downregulation, and Macrophage Reprogramming

Advanced Science, EarlyView.
FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu, Daixing Hu, Shixue Liu, Lei Yang, Junwu Li, Yuanyuan Bai, Guozhi Zhao, Wei Tang, Li Jiang   +8 more
wiley   +1 more source

DUSP11 is an Intracellular Innate Immune Checkpoint in Lung Adenocarcinoma. [PDF]

Cancer Immunol Res
Thomas BJ, Bai X, Cryer BJ, Escobar SM, Allen LH, Daniels MA, Lange MJ, Burke DH.   +7 more
europepmc   +1 more source

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenke, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

Stage- and smoking-associated microRNA expression in lung adenocarcinoma. [PDF]

Transl Lung Cancer Res
Huang M, Ge Y, Chen H, Wei C, Cogdell D, Ivan C, Chen M, Zhang W, Calin GA, Guo M.   +9 more
europepmc   +1 more source

Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma

, 2018
Xiaoxia Wang, Wujian Xu, Ping Zhan, Tianxiang Xu, Jiajia Jin, Yingying Miu, Zejun Zhou, Qingqing Zhu, Bing Wan, Guangmin Xi, Ye Liang, Yafang Liu, Jianwei Gao, Huijuan Li, Tangfeng Lv, Yong Song   +15 more
openalex   +1 more source

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Bmi-1-shRNA Inhibits the Proliferation of Lung Adenocarcinoma Cells by Blocking the G1/S Phase Through Decreasing Cyclin D1 and Increasing p21/p27 Levels

, 2014
Xiangyu Zheng, Yi-Fang Wang, Ben Liu, Chunqing Liu, Dandan Liu, Jie Zhu, Chunhui Yang, Jiangzhou Yan, Xiao‐Bo Liao, Xiuxiang Meng, Hong Yang   +10 more
openalex   +1 more source

Coexistent Primary Lung Adenocarcinoma and Mantle Cell Lymphoma: A Case Report [PDF]

, 2015
Masooma Aqeel, Nevin Uysal-Biggs, Timothy S. Fenske   +2 more
openalex   +1 more source

CELLama: Foundation Model for Single Cell and Spatial Transcriptomics by Cell Embedding Leveraging Language Model Abilities

Advanced Science, EarlyView.
CELLama is created, a framework that harnesses language models to convert cellular data into “sentences” that represent gene expression and metadata, enabling a universal embedding of cells. Unlike most single‐cell foundation models, CELLama supports scalable analysis and offers flexible applications including spatial transcriptomics.
Jeongbin Park, Sumin Kim, Jiwon Kim, Dongjoo Lee, Sungwoo Bae, Haenara Shin, Daeseung Lee, Hongyoon Choi   +7 more
wiley   +1 more source

Clinical significance and immune effect of expression of NUF2 in lung adenocarcinoma. [PDF]

Medicine (Baltimore)
Yang X, Duan F, Li S, Wang G.
europepmc   +1 more source