Results 261 to 270 of about 2,251,685 (405)
Efficacy of Neratinib-Based Therapy in ERBB2-Mutant Lung Adenocarcinomas: Findings From 2 International Phase 2 Studies
Bob T. Li, Leena Gandhi, Vignesh Ravichandran, Benjamin Besse, Julien Mazières, Geoffrey I. Shapiro, Valentina Boni, Saiama N. Waqar, Haeseong Park, David I. Quinn, Alejandro Martínez, Salomon M. Stemmer, Alexis B. Cortot, Fabrice Barlési, Élisabeth Quoix, Mark E. Burkard, S. Duygu Selçuklu, C. Anthony Hunt, Mark T.A. Donoghue, Mark G. Kris, Judith D. Bebchuk, Lisa D. Eli, Leanne McCulloch, David B. Solit, Pasi A. Jänne +24 moreopenalex +2 more sourcesIrradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils
Advanced Science, EarlyView.Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan +18 morewiley +1 more sourceSomatic mutations affect key pathways in lung adenocarcinoma
Nature, 2008 L. Ding, G. Getz, D. Wheeler, E. Mardis, M. McLellan, K. Cibulskis, C. Sougnez, H. Greulich, D. Muzny, M. Morgan, L. Fulton, R. Fulton, Qunyuan Zhang, M. Wendl, M. Lawrence, D. Larson, Ken Chen, D. Dooling, A. Sabo, A. Hawes, Hua Shen, S. Jhangiani, L. Lewis, O. Hall, Yiming Zhu, T. Mathew, Yanru Ren, Jiqiang Yao, S. Scherer, Kerstin Clerc, G. Metcalf, Brian Y. Ng, A. Milosavljevic, M. Gonzalez-Garay, John R. Osborne, R. Meyer, Xiaoqi Shi, Yuzhu Tang, D. Koboldt, Ling Lin, R. Abbott, T. Miner, C. Pohl, Ginger A. Fewell, C. Haipek, Heather K. Schmidt, Brian H. Dunford-Shore, A. Kraja, S. Crosby, Christopher Sawyer, T. Vickery, Sacha N Sander, J. Robinson, W. Winckler, J. Baldwin, L. Chirieac, A. Dutt, T. Fennell, M. Hanna, B. Johnson, R. Onofrio, Roman K. Thomas, G. Tonon, B. Weir, Xiaojun Zhao, L. Ziaugra, M. Zody, T. Giordano, M. Orringer, J. Roth, M. Spitz, I. Wistuba, B. Ozenberger, P. Good, A. Chang, D. Beer, M. Watson, M. Ladanyi, S. Broderick, A. Yoshizawa, W. Travis, W. Pao, M. Province, G. Weinstock, H. Varmus, S. Gabriel, E. Lander, R. Gibbs, M. Meyerson, R. Wilson +89 moresemanticscholar +1 more sourceA20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β
Advanced Science, EarlyView.This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.Fan Luo, Ting Yang, Jiaxin Cao, Qun Chen, Zhenhai Lu, Feiteng Lu, Chaozhuo Lin, Zengfei Xia, Yuanzhong Yang, Peng Li, Wenjuan Ma, Min Luo, Rongxin Zhang +12 morewiley +1 more sourceReal‐Time In Vivo Cellular‐Level Imaging During Puncture
Advanced Science, EarlyView.We present an artificial‐intelligence‐empowered integrative‐light‐field microendoscopy (AIM) needle that delivers real‐time in vivo, diffraction‐limited cellular‐level imaging during puncture and visualizes layered microstructures along the needle path. As a microscopic complement to CT/ultrasound, it improves sampling localization and adds preliminary Huifang Gao, Jiakang Shao, Quanzhi Li, Yizhou Tan, Liangliang Huang, Xiaorong Xu, Ji Qi, Julin Xiao, Wenwen Li, Zhong Wen, Le Wang, Xu Liu, Qing Yang, Ying Gu +13 morewiley +1 more source
