Results 331 to 340 of about 2,251,685 (405)

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

Advanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su, Guang Li, Yudong Guan, Qi Tian, Youzhi Qi, Yanqiu Zhang, Wenqian Wei, Xinxin Duan, Jiaxin Rui, Hongyan Zhu, Zengping Lin, Changchuan Xie, Zheni Xu, Yaying Wu, Xin Peng, Zhenjie Wang, Kun Chen, Xiaoyan Xin, Bing Zhang   +18 more
wiley   +1 more source

DeepLuAd: Semantic-guided virtual histopathology of lung adenocarcinoma via stimulated Raman scattering. [PDF]

Theranostics
Ma L, Guo Y, Du M, Cai Y, He Y, Meng Q, Liu Z, Lan Y, Li M, Ji M, Qi L.   +10 more
europepmc   +1 more source

HIV-1 and SIV Infection are associated with early loss of lung interstitial CD4+ T cells and dissemination of pulmonary tuberculosis [PDF]

, 2019
et al,, Khader, Shabaana A
core   +1 more source

Adenocarcinoma of lung

, 2013
openaire   +1 more source

Engineered Bacteria‐Vesicle Delivered Lactate Reprogramming Boosts Tumor Radiosensitivity

Advanced Science, EarlyView.
We engineered a bacterial‐vesicular dual‐delivery platform that targets LOx to colorectal tumors, enabling lactate clearance, immune microenvironment remodeling, and microbiota modulation. This microbe–metabolism synergistic strategy effectively sensitizes colorectal cancer to radiotherapy, offering a promising approach to overcome radioresistance ...
Fei Peng, Zhe Lei, Zhehao Zhang, Zhiyue Su, Chonghai Zhang, Huan Yang, Shu Liu, Mengyuan Hu, Yuhong Wang, Lingchuan Guo, Lin Hu, Kai Yang   +11 more
wiley   +1 more source

A Case of Lung Adenocarcinoma With Concurrent EGFR Mutation and ALK Fusion Combined With Literature Review. [PDF]

Clin Case Rep
Chen Y, Qi F, Zeng Y, Tan J, Hu M, Zhang H, Zhang T.   +6 more
europepmc   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

SLIT2 inhibits lung adenocarcinoma progression by suppressing epithelial-mesenchymal transition. [PDF]

Discov Oncol
Chen Z, Chen H, Cui Y, Chen J, Zeng W, Yang J, Li Y, Peng X, Tong X, Zhao J.   +9 more
europepmc   +1 more source

Lung adenocarcinoma with multiple cavitary lung lesions

Thorax
Tomohiro Bando, Wataru Koike, Kazuko Watanabe, Tadayoshi Hirano, Yumiko Sasaki   +4 more
openaire   +3 more sources

Multinodular lung adenocarcinoma

, 2021
openaire   +1 more source