Results 21 to 30 of about 6,940,670 (314)

Research Progress of Epigenetics in Pathogenesis and Treatment of Malignant Tumors

Chinese Journal of Lung Cancer, 2020
Epigenetic modification is closely related to the occurrence and development of tumors. It mainly regulates gene function and expression level through DNA methylation, histone modification, regulation of non-coding RNA and chromatin structure ...
Pan WANG, Honglin ZHAO, Fan REN, Qingchun ZHAO, Ruifeng SHI, Xingyu LIU, Jinghao LIU, Yongwen LI, Ying LI, Hongyu LIU, Jun CHEN   +10 more
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EML4-ALK-mediated activation of the JAK2-STAT pathway is critical for non-small cell lung cancer transformation

BMC Pulmonary Medicine, 2021
Background The echinoderm microtubule-associated protein-like-4 anaplastic lymphoma kinase (EML4-ALK) fusion gene was identified in a subset of non-small cell lung cancer (NSCLC) patients. They responded positively to ALK inhibitors.
Ying Li, Yongwen Li, Hongbing Zhang, Ruifeng Shi, Zihe Zhang, Hongyu Liu, Jun Chen   +6 more
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First‐Line Atezolizumab plus Chemotherapy in Extensive‐Stage Small‐Cell Lung Cancer

New England Journal of Medicine, 2018
BACKGROUND Enhancing tumor‐specific T‐cell immunity by inhibiting programmed death ligand 1 (PD‐L1)–programmed death 1 (PD‐1) signaling has shown promise in the treatment of extensive‐stage small‐cell lung cancer.
L. Horn, A. Mansfield, A. Szczesna, L. Havel, M. Krzakowski, M. Hochmair, F. Huemer, G. Losonczy, M. Johnson, M. Nishio, M. Reck, T. Mok, S. Lam, D. Shames, Juan Liu, B. Ding, A. López-Chávez, F. Kabbinavar, W. Lin, A. Sandler, Stephen V. Liu   +20 more
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NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 2.2021.

The Journal of the National Comprehensive Cancer Network, 2021
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Non-Small Cell Lung Cancer (NSCLC) address all aspects of management for NSCLC.
D. Ettinger, D. Wood, D. Aisner, W. Akerley, J. Bauman, A. Bharat, D. Bruno, Joe Y. Chang, L. Chirieac, T. D’amico, T. Dilling, J. Dowell, S. Gettinger, M. Gubens, A. Hegde, M. Hennon, R. Lackner, M. Lanuti, T. Leal, Jules Lin, B. Loo, C. Lovly, R. Martins, E. Massarelli, D. Morgensztern, T. Ng, G. Otterson, S. Patel, Gregory Riely, S. Schild, T. Shapiro, Aditi P. Singh, J. Stevenson, A. Tam, J. Yanagawa, Stephen C. Yang, K. Gregory, M. Hughes   +37 more
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Lymph node metastasis in lung squamous cell carcinoma and identification of metastasis‐related genes based on the Cancer Genome Atlas

Cancer Medicine, 2019
Squamous cell carcinoma (SCC) is a unique clinical and histological category that accounts for about 30% of total lung cancer. To identify risk factors for lymph node metastasis and analyze the molecular features of these metastases in lung SCC, a ...
Ming Dong, Hao Gong, Tong Li, Xin Li, Jinghao Liu, Hongbing Zhang, Minghui Liu, Gang Chen, Hongyu Liu, Jun Chen   +9 more
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Primary chondroma of posterior mediastinum with Horner’s syndrome: a case report

World Journal of Surgical Oncology, 2018
Background Chondroma is a slowly growing, benign cartilaginous tumor which predominantly occurs in long bones of the hands and feet. Primary mediastinal chondroma is rare, especially with Horner’s syndrome.
Xiaoqian Xu, Xin Li, Fan Ren, Ming Dong, Minghui Liu, Jun Chen   +5 more
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Global burden and trends of lung cancer incidence and mortality

Chinese Medical Journal, 2022
Background: Lung cancer has been the leading cause of cancer-related deaths worldwide for many years. This study aimed to investigate the global patterns and trends of lung cancer.
Chao Li, S. Lei, L. Ding, Yan Xu, Xiaonan Wu, Hui Wang, Zijin Zhang, Ting Gao, Yongqiang Zhang, Lin Li   +9 more
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Effect of Upper Arm Position Changes on the Occurrence of Ipsilateral Shoulder Pain After Single-Operator Port Thoracoscopy

Frontiers in Surgery, 2022
BackgroundThe aim of this study was to explore the factors associated with the occurrence of ISP after VATS to reduce the incidence of ISP and improve patients' quality of life.MethodsThe data of patients were collected between June 2020 and August 2020 ...
Dian Ren, Bo Zhang, Jie Xu, Renwang Liu, Jing Wang, Huandong Huo, Hao Zhang, Jingtong Zeng, Hanqing Wang, Xiaohong Xu, Mei Lin, Song Xu, Song Xu, Zuoqing Song, Zuoqing Song   +14 more
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Pembrolizumab plus Chemotherapy for Squamous Non–Small‐Cell Lung Cancer

New England Journal of Medicine, 2018
Background Standard first‐line therapy for metastatic, squamous non–small‐cell lung cancer (NSCLC) is platinum‐based chemotherapy or pembrolizumab (for patients with programmed death ligand 1 [PD‐L1] expression on ≥50% of tumor cells).
L. Paz-Ares, A. Luft, D. Vicente, A. Tafreshi, M. Gümüş, J. Mazières, B. Hermes, F. Senler, T. Csőszi, A. Fülöp, J. Rodríguez-Cid, Jonathan Wilson, S. Sugawara, T. Kato, K. Lee, Ying Cheng, S. Novello, B. Halmos, Xiaodong Li, G. Lubiniecki, B. Piperdi, D. Kowalski   +21 more
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Identification of a novel oxidative stress-related prognostic model in lung adenocarcinoma

Frontiers in Pharmacology, 2022
Background: Oxidative stress (OxS) participates in a variety of biological processes, and is considered to be related to the occurrence and progression of many tumors; however, the potential diagnostic value of OxS in lung cancer remains unclear.Methods:
Yifan Zhu, Yifan Zhu, Quanying Tang, Quanying Tang, Weibo Cao, Weibo Cao, Ning Zhou, Ning Zhou, Xin Jin, Xin Jin, Zuoqing Song, Zuoqing Song, Lingling Zu, Lingling Zu, Song Xu, Song Xu   +15 more
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